Date: 26 November 2013
22/09/08 This chest radiograph shows bilateral hazy diffuse airspace disease predominating in the lower lungs with subtle nodularity in upper zones.
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Notes:
A 33 year old known Chronic Granulomatous Disorder (CGD) male presented to A&E in respiratory distress and admitted with severe bibasal pneumonia. He had been laying mulch in his garden. He had not been taking any prophylactic antifungal agents. Oxygen therapy was commenced in conjunction with IV bacterial and fungal treatment with Amphotericin B (Fungizone ®). Further consultation and an adverse reaction to the administration of Fungizone ® led to a switch to IV Voriconazole 300mg BD. The patient tested positive for aspergillus antibodies in serum. The patient declined a bronchoscopy, responded well to IV voriconazole and was discharged home 2 weeks post admission on maintenance voriconazole.
Images library
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Disseminated aspergillosis in a German Shepherd. Hyphae of Aspergillus terreus in the urine of a young German Shepherd dog with disseminated aspergillosis. White blood cells are present in addition to the fungal hyphae. Wet preparation of urine; magnification x 132.
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Aflatoxicosis – advertisement for a sports drink in China, supposed to remove aflatoxin.
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Aflatoxicosis – Kenya, 1982- 20 cases of aflatoxicosis described and 12 deaths. Aflatoxin was detectable at 3.2-12mg/kg in food samples.
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Light microscopical appearance of hepatic tissue in outbreak of aflatoxicosis showing centrilobular collapse with reticular condensation (Reticulin).
