Aspochalasin H - Aspergillus and Aspergillosis

Date:

TAIJIRO TOMIKAWA, KAZUO SHIN-YA, HARUO SETO, NORIYUKI OKUSA, TAKAYUKI KAJIURA, YOICHI HAYAKAWA, Structure of Aspochalasin H, a New Member of the Aspochalasin Family, The Journal of Antibiotics, 2002, Volume 55, Issue 7, Pages 666-668, Released on J-STAGE January 27, 2009, Online ISSN 1881-1469, Print ISSN 0021-8820, https://doi.org/10.7164/antibiotics.55.666, https://www.jstage.jst.go.jp/article/antibiotics1968/55/7/55_7_666/_article/-char/en

Notes:

Structure of Aspochalasin H

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Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

A colour enhanced image.
Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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