Chen XW, Li CW, Cui CB, Hua W, Zhu TJ, Gu QQ. Nine new and five known polyketides derived from a deep sea-sourced Aspergillus sp. 16-02-1. Mar Drugs. 2014 May 27;12(6):3116-37. doi: 10.3390/md12063116. PMID: 24871461; PMCID: PMC4071568.
Notes:
Structure of Aspilactonol B: C-8 = S, C-9 = R (Aspilactonol C: C-8 = R, C-9 = S)
Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.
Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.
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![Asp[1]niger](https://www.aspergillus.org.uk/wp-content/uploads/2013/11/Asp1niger-150x150.gif "Asp[1]niger")
