Kindly provided by Iván Solano Leiva, Infectious Diseases MD, Instituto Salvadoreno del Seguro Social, El Salvador.
Notes:
A 54 yr old male patient who underwent a renal transplant one year earlier. The patient noticed a lesion on left plantar region, it was not painful but was slowly enlarging (over 9 months). In the latter 3 months the lesion became slightly purulent. Multiple cycles of antibiotics gave no improvemnt. Culture of the discharge produced Aspergillus niger. The final diagnosis of this patient was Aspergillus osteomyelitis. The patient was treated with voriconazole orally 200 mg twice daily.
PAS stain. An example of Aspergillus fumigatus.
(PAS-stained) in a patient with chronic granulomatous disease showing a 45 degree branching hypha within a giant cell. Rather bulbous hyphal ends are also seem, which is sometimes found inAspergillus spp. infections, histologically. (x800)
