A new spiroketal from Aspergillus terreus, an endophytic fungus in Opuntia ficusindica Mill. Journal of Basic Microbiology 48, 140–142. Shao-Hua Wu1, You-Wei Chen1, Sheng Qin1 and Rong Huang (2008) Journal of Basic Microbiology (2008), 48(2), 140-142.
Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.
Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.