ALL with disseminated aspergillosis associated with Aspergillus flavus infection

Date: 3 February 2014

  • Image A

  • Image B

  • Image C

  • Image D

  • Image E

  • Image F

  • Image G

  • Image H

  • Image I

  • Image J

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This patient was 28 yr old with adult lymphocytic leukaemia. She received induction chemotherapy and this infection developed 2 days after recovering from neutropenia.

Copyright:

These images were kindly donated by Maria Cecilia Dignani, MD, Head Infectious Diseases, Fundaleu, Buenos Aires, Argentina. September 2007

(© Fungal Research Trust)

Notes:

A,B,&C the patient had multiple erythematous lesions on the skin, some of the lesions were papular and showed necrotic tissue.

D,E,F & G MRI brain scans showed multiple bilateral nodular lesions in the frontal, parietal and occipital areas. Lesions were 0.7 – 2cm in diameter involving both peripheral and central areas of the brain. G– illustrates a small well defined lesion in the posterior fossa.

H,I & J CT scans of lungs showing nodular lesions in both lungs with infiltrates. I – exhibits the classic halo sign – suggestive of aspergillus infection. J illustrates that some associated pleural effusion was present.

The patient was exposed to high levels of mould during treatment for ALL as a result of a leaking pipe and extensive mould damage to wallcoverings in her home.

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