A Lys-EGFP mouse was infected with swollen A. fumigatus conidia and 7 h later the lung was prepared as described in movie 3. The sequence shows several neutrophils (green) migrating within lung tissue (blue). Red staining is from the DNA-specific dye Sytox Orange showing cell nuclei cut open by the preparation. Please note the active motility of cells within the tissue. Indicated is a scale bar and real time in minutes.
Reference: Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA. Bruns et. al. PLoS Pathog. 2010 Apr 29;6(4):e1000873.
http://www.plospathogens.org/article/…
Medical and Patient education videos
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Title
Description
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Dr. Rohini Manuel, Consultant Clinical Microbiologist, Public Health England, London
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Shila Seaton, Bacteriology Scheme Manager, UK NEQAS for Microbiology, Public Health England
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Dr. P. Lewis White, Principal Clinical Scientist, Public Health Wales Microbiology, Cardiff
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Prof. Dr. Clemens Decristoforo, Radiopharmacist, Univ.Klinik f.Nuklearmedizin, Innsbruck, Austria
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Dr. Martin Hoenigl, Infectious Diseases and Tropical Medicine, Medical University of Graz, Austria
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Dr. Jonathan Lambourne, Consultant in Infectious Diseases, Barts Health NHS Trust, London
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Dr. Inês Ushiro-Lumb, Lead Clinical Microbiologist for Organ Donation and Transplantation, NHS Blood and Transplant, London
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Dr. Mike Bromley, Lecturer, Institute of Inflammation and Repair, University of Manchester
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Dr. Sharleen Braham, Clinical Scientist, King’s College Hospital, London
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Dr. Duncan Wilson, Research Fellow, Aberdeen Fungal Group, University of Aberdeen