After 180 minutes of neutrophil-Aspergillus co-incubation a well established NET is visible. At the beginning of the movie (0 min) DNase I was added to the medium. At 7 minutes digestion of the NET started and was finished (no NET structure detectable) by 9.5 minutes into the experiment. Indicated is a scale bar and real time in minutes.
Reference: Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA. Bruns et. al. PLoS Pathog. 2010 Apr 29;6(4):e1000873.http://www.plospathogens.org/article/…
Medical and Patient education videos
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Title
Description
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Powerpoint presentation December 2009
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Published on 23 Apr 2014.
Wild Type A. fumigatus strain differences and antifungal susceptibility in Invasive Pulmonary Aspergillosis
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Published on 18 Jun 2014 CT scan image of a dog with Nasal Aspergillosis
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Uploaded on 11 Feb 2012 Dr. Sunena Argo discusses the diagnosis and management of ABPA
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Uploaded on 12 Feb 2012 Dr. Heather Doss reviews the diagnosis and management of ABPA. Held on Oct 17, 2011.
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Published on 28 Dec 2012 Developed and produced for http://www.MechanismsinMedicine.com Animation Description: One of the most lethal complications of invasive aspergillosis is dissemination to the brain. The diagnosis is difficult and it has been associated with near 100% mortality, however aggressive antifungal therapy can improve outcomes. Watch this animation for more information.
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“With every breath you take, you are inhaling a potentially deadly pathogen. You can’t see this parasite floating into your nostrils and weaving its way down into your lungs. You probably breathe many of them right back out again, but some stick with every breath. If you’re a healthy non-smoker, have no fear, your immune system has an excellent chance of destroying the invaders before they can make you sick. If your lungs or immune system are compromised, you still have an excellent chance of escaping these frequent attacks unscathed. But, for the unlucky few among us, the fungal pathogen Aspergillus might just win. Let’s take a closer look and see what we could be in for.”
An online science educational resource – intended for students but is suitable for the layperson.
Requires registration for a free trial.
