Itaconic acid

ID 2: 601

Toxin: n

Trivial name:

Butanedioic acid, methylene- (9CI); Succinic acid, methylene- (8CI); 2-​Methylenebutanedioic acid; 2-​Methylenesuccinic acid; 2-​Propene-​1,​2-​dicarboxylic acid; 4-​Hydroxy-​2-​methylene-​4-​oxobutanoic acid; Itaconic acid; Methylenebutanedioic acid; Methylenesuccinic acid; NSC 3357; Propylenedicarboxyli​c acid

Systematic name:

Butanedioic acid, 2-​methylene-

Molecular formulae: 

C₅H₆O₄

Molecular weight: 130.10

Chemical abstract number: 97-65-4

Literature reference:

• Formation of itaconic acid and mannitol by a new filamentous fungus. Kinoshita, Kono. Nippon Kagaku Kaishi (1921-47) (1929), 50, 583-93.
  The biochemistry of micro-organisms. LXIII. Itaconic acid, a metabolic product of a strain of Aspergillus terreus Thom. Calam, Christopher T.; Oxford, Albert E.; Raistrick, Harold. Biochemical Journal (1939), 33, 1488-95.
  Metabolism of aromatic compounds by fungi. Kinetic properties and mechanism of 3-​carboxy-​cis,​cis-​muconate cyclase from Aspergillus niger. Thatcher, David R.; Cain, Ronald B. European Journal of Biochemistry (1975), 56(1), 193-204. Thatcher, David R.; Cain, Ronald B. European Journal of Biochemistry (1975), 56(1), 193-204.
  Isolation and biological evaluation of two bioactive metabolites from Aspergillus gorakhpurensis. Busi, Siddhardha; Peddikotla, Prabhakar; Upadyayula, Suryanarayana M.; Yenamandra, Venkateswarlu. Records of Natural Products (2009), 3(3), 161-164.
  Itaconic acid derivatives and diketopiperazine from the marine-​derived fungus Aspergillus aculeatus CRI322-​03. Antia Bassey S; Aree Thammarat; Kasettrathat Chairut; Wiyakrutta Suthep; Ekpa Okon D; Ekpe Udofot J; Mahidol Chulabhorn; Ruchirawat Somsak; Kittakoop Prasat. Phytochemistry (2011), 72(8), 816-20.
  Optimization and production of itaconic acid using Aspergillus flavus. Sudarkodi, C.; Subha, K.; Kanimozhi, K.; Panneerselvam, A. Advances in Applied Science Research (2012), 3(2), 1126-1131.

References URL: 

• http://pubchem.ncbi.nlm.nih.gov/compound/811
• https://www.jstage.jst.go.jp/article/nikkashi1921/50/10/50_10_583/_article/-char/ja/
• http://www.biochemj.org/
• http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1975.tb02222.x/abstract
• http://www.acgpubs.org/RNP/2009/Volume%203/Abstracts/23-RNP-0905_101.htm
• http://www.sciencedirect.com/science/article/pii/S0031942211000999
• http://pelagiaresearchlibrary.com/advances-in-applied-science/vol3-iss2/AASR-2012-3-2-1126-1131.pdf

Aspergillus Species known to produce this metabolite:

• /species/itaconicus
• /species/a-terreus
• /species/a-niger
• /species/a-gorakhpurensis
• /species/a-aculeatus
• /species/a-flavus

Date uploaded: 2008-07-07 16:58:01

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Mycotoxin & Metabolites

Mycotoxin & Metabolite database

Aspergillus species produce a large number of secondary metabolites, sometimes referred to as extrolites. We attempt to list them all here and we also collect published papers.

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