Dihydromevinolin

ID 2: 229

Toxin: n

Trivial name:

Butanoic acid, 2-​methyl-​, 1,​2,​3,​4,​4a,​7,​8,​8a-​octahydro-​3,​7-​dimethyl-​8-​[2-​(tetrahydro-​4-​hydroxy-​6-​oxo-​2H-​pyran-​2-​yl)​ethyl]​-​1-​naphthalenyl ester, [1S-​[1α(R*)​,​3α,​4aα,​7β,​8β(2S*,​4S*)​,​8aβ]​]​-; (+)​-​Dihydromevinolin; Dihydrolovastatin; Dihydromevinolin; L 154883; MSD 883

Systematic name:

Butanoic acid, 2-methyl-, (1S,3S,4aR,7S,8S,8aS)-1,2,3,4,4a,7,8,8a-octahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-

Molecular formulae: 

C24H38O5

Molecular weight: 406.56

Chemical abstract number: 77517-29-4

Literature reference:

  • Polyhydro-​3,​7-​dimethyl-​8-​(2-​(tetrahydro-​4-​hydroxy-​6-​oxo-​2H-​pyran-​2-​yl)​-​ethyl)​-​1-​napththylenyl-​2-​methylbutanoates, their hydroxy acids and pharmaceutical compositions containing them. Monaghan, Richard L.; Alberts, Alfred W.; Hoffman, Carl H.; Albers-Schonberg, George; Joshua, Henry; Lopez Aguirre, Maria B. Eur. Pat. Appl. (1981), EP 22478 A1 19810121.
    Hypocholesteremic fermentation products. Albers-Schonberg, George; Joshua, Henry; Lopez, Maria B. U.S. (1981), US 4294846 A 19811013.
    Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus. Albers-Schonberg, G.; Joshua, H.; Lopez, M. B.; Hensens, O. D.; Springer, J. P.; Chen, J.; Ostrove, S.; Hoffman, C. H.; Alberts, A. W.; Patchett, A. A. Journal of Antibiotics (1981), 34(5), 507-12.

References URL: 

Aspergillus Species known to produce this metabolite:

Structure image:  

dihydromevinolinweb

Date uploaded: 2008-07-07 16:08:30

Mycotoxin & Metabolites

Mycotoxin & Metabolite database

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