Macrophages, TLR – BTK signaling and Aspergillus fumigatus

Author:

Dr Darius Armstrong-James

Author address:

Imperial College, London

Full conference title:

13th Annual Fungal Update

Date: 9 July 2020

Abstract:

The Bruton’s tyrosine kinase (Btk) inhibitor Ibrutinib has become a major antiproliferative therapy for CLL and other malignancies as well as in some autimmune conditions. Its primary mode of action is to block B cell responses via the B cell receptor. We recently showed, however, that Btk is essential for endosmal responses to Aspergillus fumigatus in macrophages. Recent data now shgows a high risk of invasive aspergillosis in patients taking combination immunosuppressive therapy including Ibrutinib. In this presentation I will outline our understanding of how risk is conferred and our current data on the effects of Ibrutinib on macrophage responses to A. fumigatus

Abstract Number: 1000

Link to conference website:

Link Conference abstract: 

Fungal Update 2018

Link to talk: 

Link to talk

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