Clinical and immunological characteristics of fungal sensitive asthma and allergic bronchopulmonary Aspergillosis

Author:

Zheng P; Sun B

Author address:

Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Full conference title:

European Academy of Allergy and Clinical Immunology Congress 2017

Date: 20 August 2020

Abstract:

Introduction: ABPA is currently believed to be an exaggerated form of Aspergillus sensitization, and is probably the first step in its development.

Objectives: The aim of this study was to investigate the clinical and immunologic characteristics of fungal-sensitive asthma (FA), nonfungal-sensitive asthma(NFA) and ABPA.

Results: Prevalence of bronchiectasis (88.9%), as well as eosinophil number in sputum [13.0(1.5, 23.5)%], eosinophil number in blood [0.85(0.30, 1.41)*10^9/L], erythrocyte sedimentation rate [22(15, 40)] and dose of oral corticosteroid[15(10, 20)mg]) in the ABPA group was higher than that in the NFA group [20%; 3.5(1.5, 10.7) %; 0.14(0.01, 0.53)*10^9/L; 10(5, 35)mm/h; 10(0, 20) mg; P<.05]and FA group [25.6%; 11.5(6.5, 45.5) %; 0.15(0.00, 0.30) *10^9/L; 9(4, 17) mm/h; 10(0, 25) mg; P<.05].The FVC%pred [78.30(66.0, 89.0)%] and FEV1%pred [55.024.4%] in ABPA are significantly lower than those in NFA[89.3(78.7, 102.1)%; 70.224.0%; P<.05];Level of sIgE-M.x [4.63(0.97, 13.45)kU/L], sIgE-A.f [7.95(1.00, 26.13) kU/L], sIgG-A.f [82.5(22.7, 166.0) mgA/L] and total IgE [1332(1000, 3291) kU/L] in the ABPA group was higher than that in the FA group[0.66(0.45, 1.48) kU/L; 0.61(0.42, 2.80) kU/L; 18.3(7.6, 37.7)mgA/L; 992(293, 2123) kU/L]. sIgE-A.f. was negatively and linearly correlated with FVC% predicted, FEV1% predicted, PEF% predicted, and FEF25-75% predicted.

Conclusions: There were different clinical and immunological features among NFA, FA and ABPA. The ABPA had worse function as well as higher percentage of bronchiectasis, and higher dose of oral corticosteroid. Besides, the sensitivity to aspergillus was more severe in ABPA. The level of sIgE-A.f was associated with the damage of lung function.

Abstract Number: 0571

Link to conference website:

Link Conference abstract: 

EAACI 2017

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