Association between sensitization to mold and impaired pulmonary function in children with asthma

Author:

Yoo, Y 1,2; Kim, E 1; Ri, S 1; Amarsalkhan, O 1; Song, DJ 1;Choung, JT 1

Author address:

1 Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea; 2
Allergy & Immunology Center, Korea University, Seoul, Korea

Full conference title:

European Academy of Allergy and Clinical Immunology Congress 2016

Date: 5 August 2020

Abstract:

Background: Recent data indicate that sensitization to mold may contribute to the severity and persistence of asthma symptoms. The aim of this study was to examine the relationships between sensitization to mold and pulmonary function parameters in children with asthma.

Method: A total of 551 children with asthma were recruited by Allergy Clinic of Korea University Anam Hospital. They underwent spirometry, methacholine challenge tests, and measurement of blood eosinophils, serum IgE and concentrations of eosinophil cationic protein (ECP) and exhaled nitric oxide (NO). Skin prick test with common aeroallergens in South Korea including house dust mites (Dermatophagoides pteronyssinus, Dermatophagoides farinae), animal dander (cat, dog), pollen, cockroach and mold allergens (Alternaria alternata, Aspergillus fumigatus) was performed. Children were divided into 3 groups according to their sensitization profiles. Children who did not show positive result to any aeroallergen were designated as Group 1. Group 2 represented children who sensitized to aeroallergens other than mold and Group 3 included children who sensitized to mold allergens.

Results: Among the 551 children, 441 (78.6%) showed a positive response to at least 1 aeroallergen. Three hundreds and seventy-five (86.6%) children were sensitized to house dust mites and followed by animal dander 121 (27.9%), pollen 117 (27.0%), cockroach 37 (8.5%), and mold 67 (15.5%). The mean ( SD) FEV1 in children with Group 3 (86.9 12.1%pred) was significantly lower than those of the Group 1 (93.4 15.4%pred) and Group 2 (92.0 14.8%pred). The log mean ( SD) methacholine PC20 in children with Group 3 (0.08 1.91 mg/ml) was significantly lower than those of the: Group 1 (2.29 1.66 mg/ml). Group 2 (1.31 1.69 mg/ml). Blood IgE levels and eosinophil profiles were significantly higher in the Groups 2 and 3 than those of the Group 1 but no significant difference was found between the former 2 groups.

Conclusion: Sensitization to mold is associated with severe asthma, particularly lower lung function and severe bronchial hyperresponsiveness in children with asthma. However, it may not be necessarily related to eosinophilic inflammation.

Abstract Number: 542

Link to conference website:

Link Conference abstract: 

EAACI 2016

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