A Comparison of Terbinafine (Lamisil(R)) 1-Percent Cream Given for One Week with Clotrimazole (Canesten(R)) 1-Percent Cream Given for 4 Weeks, in the Treatment of Tinea-Pedis

Ref ID: 669

Author:

Evans, E. G. V.

Author address:

Evans, egv, univ leeds,dept microbiol,phls,mycol reference lab,leeds ls2 9jt,w yorkshire,england

Full conference title:

Symposium on Lamisil: A New Measure in Antifungal Therapy in Skin and Nail Disease, at Dermatology 2000

Date: 7 April 1994

Abstract:

Terbinafine (Lamisil(R)) is a synthetic allylamine antifungal which has been shown to be fungicidal against dermatophytes and a number of yeasts and moulds. Topical application of terbinafine 1% cream has been shown to be a highly effective short-duration therapy for dermatophytosis of the skin. The aim of this multicentre, double-blind, parallel-group study was to compare the safety and efficacy of terbinafine 1% cream, applied twice daily for 1 week, with clotrimazole (Canesten(R)) 1% cream, applied twice daily for 4 weeks, in the treatment of tinea pedis.One hundred and seven patients with mycologically proven tinea pedis received 1 week of terbinafine 1% cream, followed by 3 weeks of placebo, and 104 patients received clotrimazole 1% cream for 4 weeks. Mycological cure (negative microscopy and culture) and effective treatment (mycological cure with no or minimal signs and symptoms) were assessed 4 and 6 weeks after commencing therapy.Mycological cure rates were 93.5% for terbinafine and 73.1% for clotrimazole (P=0.0001) at 4 weeks, and 97.2% for terbinafine and 83.7% for clotrimazole (P=0.001) at 6 weeks. Effective treatment rates at 4 weeks were 89.7% for terbinafine and 58.7% for clotrimazole (P=0.0001), and 89.7% for terbinafine and 73.1% for clotrimazole (P=0.002) at 6 weeks.The results show that 1 week of terbinafine b.d. is more effective than 4 weeks of clotrimazole b.d., in terms of both mycological cure and effective treatment.

Abstract Number: NULL

Conference Year: 1993

New link: NULL

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