Disseminated Histoplasmosis in Costa Rica and the Use of Amphotericin B deoxycholate and Fluconazole as First Line of Theraphy
Author:
M. A. Villalobos, S. M. Rodriguez
Date: 25 September 2013
Abstract:
The histoplasmosis is an infectious disease caused by the dimorphic fungus Histoplasma capsulatum, particularly in those with deficience in their celular inmunity like HIV. The International Guidelines define the first line of therapy against histoplasmosis with Liposomal Amphotericin B therapy until the clinical condition improve, and then switched to itraconazole. In Costa Rica in order to avoid drug interactions with other medications like antiretrovirals we use Amphotericin B deoxycholate switched to fluconazole as first line of therapy in our institution.
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