Secondary metabolites, 3D structure: Trivial name – sphingofungin B

Date: 26 November 2013

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Secondary metabolites, 3D structure: Trivial name – sphingofungin B

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Notes:

Species: A. fumigatusSystematic name: 6-Eicosenoic acid, 2-amino-3,4,5,14-tetrahydroxy- (2S,5S,3R,4R,14R)-2-Amino-3,4,5,14-tetrahydroxyicos-6-enoic acidMolecular formulae: C20H39NO6Molecular weight: 389.527Chemical abstracts number: 121025-45-4Selected references: VanMiddlesworth F, Giacobbe RA, Lopez M, Garrity G, Bland JA, Bartizal K, Fromtling RA, Polishook J, Zweerink M, Edison AM, et al. J Antibiot (Tokyo). 1992 Jun;45(6):861-7. Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.Zweerink MM, Edison AM, Wells GB, Pinto W, Lester RL. Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase. J Biol Chem. 1992 Dec 15;267(35):25032-8.

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    Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
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    Ira F. Salkin 1941-2016