Fumigaclavine A

ID 2: 489

Toxin: y

Trivial name: Ergolin-​9-​ol, 6,​8-​dimethyl-​, acetate (ester)​, (8α,​9β)​- (9CI); Fumigaclavine A (6CI,​7CI,​8CI); Indolo[4,​3-​fg]​quinoline, ergolin-​9-​ol deriv.

Systematic name:

Ergolin-9-ol, 6,8-dimethyl-, acetate (ester), (8-alpha,9-beta)-

Molecular formulae: 

C18 H22 N2 O2

Molecular weight: 298.38

Chemical abstract number: 6879-59-0

Chemical type: clavine alkaloid

Literature reference:

  • Isolation of festuclavine and two new clavine alkaloids from Aspergillus fumigatus. Spilsbury, J. F.; Wilkinson, S. Journal of the Chemical Society (1961), 2085-91.
    Production of fumigaclavine A by Aspergillus tamarii Kita. Janardhanan, K. K.; Sattar, Abdul; Husain, Akhtar. Canadian Journal of Microbiology (1984), 30(2), 247-50.

References URL: 

Aspergillus Species known to produce this metabolite:

Toxicity:

The LD50 of fumigaclavine C was about 150 mg/kg oral dose in day-old cockerels. Calves dosed with crude extracts of A. fumigatus cultures experienced severe diarrhea, irritability and loss of appetite. Postmortem examination showed serous enteritis and evidence of interstitial changes in the lungs; abnormal changes were not found in other tissues.

Structure image:  

Fumigaclavineweb

Date uploaded: 2005-12-13 00:00:00


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