Compactin (Statins)

ID 2: 381

Toxin: n

Trivial name: Butanoic acid, 2-​methyl-​, 1,​2,​3,​7,​8,​8a-​hexahydro-​7-​methyl-​8-​[2-​(tetrahydro-​4-​hydroxy-​6-​oxo-​2H-​pyran-​2-​yl)​ethyl]​-​1-​naphthalenyl ester, [1S-​[1α(R*)​,​7β,​8β(2S*,​4S*)​,​8aβ]​]​-; (+)​-​Compactin; Antibiotic ML 236B; CS 500; CS 500 (antibiotic); Compactin; Compactin (Penicillium); L 637312; ML 236B; ML 236B lactone; Mevastatin; NSC 281245; Statin I

Systematic name:

[8-[2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate

Molecular formulae: 

C23H34O5

Molecular weight: 390.51

Chemical abstract number: 73573-88-3

Literature reference:

  • Biosynthesis of ML-​236C and the hypocholesterolemic agents compactin by Penicillium aurantiogriseum and lovastatin by Aspergillus terreus: determination of the origin of carbon, hydrogen and oxygen atoms by 13C NMR spectrometry and observation of unusual labeling of acetate-​derived oxygens by 18O2. Wagschal, Kurt; Yoshizawa, Yuko; Witter, David J.; Liu, Yaoquan; Vederas, John C. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1996), (19), 2357-2363.
    Production and purification of statins from Aspergillus terreus strains. Manzoni, Matilde; Rollini, Manuela; Bergomi, Silvia; Cavazzoni, Valeria. Biotechnology Techniques (1998), 12(7), 529-532.

References URL: 

Aspergillus Species known to produce this metabolite:

Structure image:  

Compactinweb

Date uploaded: 2008-07-07 15:48:31


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