Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.

Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.

Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.

This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 


Pediatrics Fungal Infections

Displaying 81 - 90 of 214
Author year
Safety and Efficacy of Micafungin in Extremely Low Birthweight Infants Schüller SS, Bauer C, Unterasinger L, Berger A 2017
A rare complication of chronic granulomatous disease in a child: constrictive aspergillus pericarditis Şişli E, Özdemir Şahan Y, Ayık MF, Nart D, Atay Y 2017
Invasive Fungal Disease in Pediatric Solid Organ Transplant Recipients Saxena S, Gee J, Klieger S, Kajon A, Petersen H, Zaoutis T, Fisher B 2017
Diagnostic Imaging and Invasive Fungal Diseases in Children Katragkou A, Fisher BT, Groll AH, Roilides E, Walsh TJ 2017
Analysis of Hypokalemia as a Side Effect of Liposomal Amphotericin in Pediatric Patients Kobayashi R, Keino D, Hori D, Sano H, Suzuki D, Kishimoto K, Kobayashi K 2017
Fungal Infections of the Central Nervous System in Children McCarthy MW, Kalasauskas D, Petraitis V, Petraitiene R, Walsh TJ. 2017
Fungal infections of the lung in children. Toma P, Bertaina A, Castagnola E, Colafati GS, D'Andrea ML, Finocchi A, Lucidi V, Mastronuzzi A, Granata C. 2017
Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update. Lehrnbecher T, Robinson P, Fisher B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, Castagnola E, Davis BL, Dupuis LL, Gaur AH, Tissing WJE, Zaoutis T, Phillips R, Sung L 2017
Fungal endocarditis in paediatrics: a review of 192 cases (1971-2016). Ganesan V, Ponnusamy SS, Sundaramurthy R. 2017
Performance of 1,3-β-D-glucan for diagnosing invasive fungal diseases in children Calitri C, Caviglia I, Cangemi G, Furfaro E, Bandettini R, Fioredda F, Amoroso L, Faraci M, Risso FM, Mattioli G, Moscatelli A, Haupt R, Castagnola E. 2017