Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.

Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.

Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.

This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 


Pediatrics Fungal Infections

Displaying 71 - 80 of 225
Author year
Risk factors for early invasive fungal infections in pediatric liver transplant recipients Pasternak Y, Rubin S, Bilavsky E, Mozer-Glassberg Y, Levy I, Nahum E, Rom E, Gurevich M, Ben-Zvi H, Ashkenazi-Hoffnung L 2018
Epidemiology of Invasive Fungal Disease in Children Pana ZD, Roilides E, Warris A, Groll AH, Zaoutis T 2017
Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children King J, Pana ZD, Lehrnbecher T, Steinbach WJ, Warris A 2017
Itraconazole Dosing and Drug Monitoring at a Tertiary Children's Hospital Leong YH1, Boast A1, Cranswick N, Curtis N, Gwee A 2018
Micafungin in invasive fungal infections in children with acute leukemia or undergoing stem cell transplantation. Styczynski J, Czyzewski K, Wysocki M, Zajac-Spychala O, Wachowiak J, Ociepa T, Urasinski T, Gryniewicz-Kwiatkowska O, Kolodziejczyk-Gietka A, Dembowska-Baginska B, Perek D, Salamonowicz M, Hutnik L, Matysiak M, Siewiera K, Frackiewicz J, Kalwak K, Badowska W, Malas Z7, Gozdzik J, Urbanek-Dadela A, Karolczyk G, Stolpa W, Sobol G, Gamrot Z, Woszczyk M, Gil L 2016
Voriconazole Antifungal Prophylaxis in Children With Malignancies: A Nationwide Study Pana ZD, Kourti M, Vikelouda K, Vlahou A, Katzilakis N, Papageorgiou M, Doganis D, Petrikkos L, Paisiou A, Koliouskas D, Kattamis A, Stiakaki E, Chatzistilianou M, Vasilatou-Kosmidis H, Polychronopoulou S, Grafakos S, Roilides E 2018
Clinical features of children with acute lymphoblastic leukemia complicated by pulmonary infection after chemotherapy [Clinical features of children with acute lymphoblastic leukemia complicated by pulmonary infection after chemotherapy]. Zhang PF, et al. Zhongguo Dang Dai Er Ke Za Zhi. 2017
Clinical and Pathological Correlation in Pediatric Invasive Pulmonary Aspergillosis. Anantasit N1,2, Nuntacharruksa N1, Incharoen P3, Preutthipan A1. 2018
Indoor fungal diversity in primary schools may differently influence allergic sensitization and asthma in children. Cavaleiro Rufo J, Madureira J, Paciência I, Aguiar L, Pereira C, Silva D, Padrão P, Moreira P, Delgado L, Annesi-Maesano I, Oliveira Fernandes E, Teixeira JP, Moreira A 2017
Efficacy and safety of caspofungin in children: systematic review and meta-analysis. Rosanova MT, Bes D, Serrano Aguilar P, Cuellar Pompa L, Sberna N, Lede R 2016