Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.

Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.

Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.

This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 


Pediatrics Fungal Infections

Displaying 201 - 210 of 214
Author year
Prospective Aspergillus galactomannan antigen testing in pediatric hematopoietic stem cell transplant recipients Steinbach WJ, Addison RM, McLaughlin L, Gerrald Q, Martin PL, Driscoll T, Bentsen C, Perfect JR, Alexander BD 2007
Antifungal therapy in children with invasive fungal infections: a systematic review Blyth CC, Palasanthiran P, O'Brien TA 2007
Safety and efficacy of a caspofungin-based combination therapy for treatment of proven or probable aspergillosis in pediatric hematological patients Cesaro S, Giacchino M, Locatelli F, Spiller M, Buldini B, Castellini C, Caselli D, Giraldi E, Tucci F, Tridello G, Rossi MR, Castagnola E 2007
Posaconazole plasma concentrations in juvenile patients with invasive fungal infection Krishna G, Sansone-Parsons A, Martinho M, Kantesaria B, Pedicone L 2007
Efficacy and safety of caspofungin therapy in children with invasive fungal infections Merlin E, Galambrun C, Ribaud P, Blanc T, Michel G, Auvrignon A, Stephan JL. 2006
Results of a multicenter retrospective study of a combined medical and surgical approach to pulmonary aspergillosis in pediatric neutropenic patients Cesaro S, Cecchetto G, Corti FD, Dodero P, Giacchino M, Caviglia I, Fagioli F, Livadiotti S, Salin F, Caselli D, Castagnola E. 2007
Fungal infections in children with cancer: a prospective, multicenter surveillance study Castagnola E, Cesaro S, Giacchino M, Livadiotti S, Tucci F, Zanazzo G, Caselli D, Caviglia I, Parodi S, Rondelli R, Cornelli PE, Mura R, Santoro N, Russo G, De Santis R, Buffardi S, Viscoli C, Haupt R, Rossi MR 2006
Diagnostic approaches for immunocompromised paediatric patients with pulmonary infiltrates. Bochennek K, Abolmaali N, Wittekindt B, Schwabe D, Klingebiel T, Lehrnbecher T. 2006
The role of fungal spores in thunderstorm asthma Dales RE, Cakmak S, Judek S, Dann T, Coates F, Brook JR, Burnett RT. 2003
Prevalence of allergic bronchopulmonary aspergillosis in cystic fibrosis in an area with a high frequency of atopy. Skov M, McKay K, Koch C, Cooper PJ. 2005