Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.

Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.

Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.

This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 


Pediatrics Fungal Infections

Displaying 201 - 210 of 225
Author year
Leukocyte oxidase: defective activity in chronic granulomatous disease Baehner RL, Nathan DG 1967
Effective management of pulmonary aspergillosis invading the thoracic spine in a child with high risk ALL requiring allogeneic bone marrow transplantation Dornbusch HJ, Sovinz P, Lackner H, Schwinger W, Benesch M, Strenger V, Urban C 2008
Fatal childhood pulmonary aspergillosis from contact with pigeons Greif Z, Moscuna M, Suprun H, Hahn E, Freundlich E 1981
Infection-related mortality in children with malignancy in England and Wales, 2003-2005 Bate J, Ladhani S, Sharland M, Chisholm J, Lamagni T, Ramsay M, Johnson A, Pebody R 2009
Chronic granulomatous disease presenting with disseminated intracranial aspergillosis Alsultan A, Williams MS, Lubner S, Goldman FD 2006
Invasive pulmonary and central nervous system aspergillosis after near-drowning of a child: case report and review of the literature Leroy P, Smismans A, Seute T 2006
Pediatric invasive aspergillosis: a multicenter retrospective analysis of 139 contemporary cases Burgos A, Zaoutis TE, Dvorak CC, Hoffman JA, Knapp KM, Nania JJ, Prasad P, Steinbach WJ 2008
Voriconazole plasma monitoring Pasqualotto AC, Shah M, Wynn R, Denning DW 2008
Invasive aspergillosis in a paediatric haematology department: a 15-year review Crassard N, Hadden H, Piens MA, PondarrÉ C, Hadden R, Galambrun C, Pracros JP, Souillet G, Basset T, Berthier JC, Philippe N, Bertrand Y 2008
Voriconazole therapy in children with cystic fibrosis Hilliard T, Edwards S, Buchdahl R, Francis J, Rosenthal M, Balfour-Lynn I, Bush A, Davies J 2005