Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.


Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.


Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.


This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 

Paediatrics

Pediatrics Fungal Infections

Displaying 21 - 30 of 203
Author year
Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative. Tischer CG, Hohmann C, Thiering E, Herbarth O, Müller A, Henderson J, Granell R, Fantini MP, Luciano L, Bergström A, Kull I, Link E, von Berg A, Kuehni CE, Strippoli MP, Gehring U, Wijga A, Eller E, Bindslev-Jensen C, Keil T, Heinrich J; ENRIECO consortium. 2011
Outdoor fungi and child asthma health service attendances. Tham R, Dharmage SC, Taylor PE, Katelaris CH, Vicendese D, Abramson MJ, Erbas B. 2014
Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10-year review. Bartlett AW, Cann MP, Yeoh DK, Bernard A, Ryan AL, Blyth CC, Kotecha RS, McMullan BJ, Moore AS, Haeusler GM, Clark JE. 2018
Fungal infections in hematopoietic stem cell transplantation in children at a pediatric children's hospital in Argentina. Gomez SM, Caniza M, Fynn A, Vescina C, Ruiz CD, Iglesias D, Sosa F, Sung L. 2018
Risk Factors for Invasive Fungal Infection in Children and Adolescents With Hematologic and Malignant Diseases: A 10-year Analysis in a Single Institute in Japan. Kobayashi R, Hori D, Sano H, Suzuki D, Kishimoto K, Kobayashi K. 2018
Primary immunodeficiency. McCusker C, Upton J, Warrington R. 2018
Primary cutaneous aspergillosis caused by Aspergillus tamarii in a premature infant with extremely low birthweight: A case report with short review. Kimura H, Mitsuto I, Taguchi R, Anzawa K, Mochizuki T. 2018
Pediatric Antibacterial and Antifungal Trials From 2007 to 2017. Thaden JT, Chiswell K, Jaffe I, Bergin SP, Yang WE, Romaine A, Roberts J, Nambiar S, Farley J, Benjamin DK Jr, Smith PB, Tsalik EL. 2018
Early bacterial and fungal infection in children receiving allogeneic stem cell transplantation for acute lymphoblastic leukemia in Argentina Gomez S, Fynn AB, Fernanda S, Cecilia V, Sung L 2018
Inherited CARD9 Deficiency: Invasive Disease Caused by Ascomycete Fungi in Previously Healthy Children and Adults Corvilain E, Casanova JL, Puel A 2018

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