Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.


Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.


Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.


This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 

Paediatrics

Pediatrics Fungal Infections

Displaying 1 - 10 of 251
Author year
Benefits of a Pediatric Antimicrobial Stewardship Program in Antimicrobial Use and Quality of Prescriptions in a Referral Children's Hospital. Velasco Arnaiz E, Simó Nebot S, Ríos Barnés M, López Ramos MG, Monsonís M, Urrea Ayala M, Jordan I, Mas Comas A, Casadevall Llandrich R, Ormazábal Kirchner D, Cuadras Pallejà D, Pérez Pérez C, Millet Elizalde M, Sánchez Ruiz E, Fortuny C, Noguera-Julian A. 2020
Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients. Lehrnbecher T, Fisher BT, Phillips B, Beauchemin M, Carlesse F, Castagnola E, Duong N, Dupuis LL, Fioravantti V, Groll AH, Haeusler GM, Roilides E, Science M, Steinbach WJ, Tissing W, Warris A, Patel P, Robinson PD, Sung L. 2020
Comparative accuracy of 1,3 beta-D glucan and galactomannan for diagnosis of invasive fungal infections in pediatric patients: a systematic review with meta-analysis. Singh S, Singh M, Verma N, Sharma M, Pradhan P, Chauhan A, Jaiswal N, Chakrabarti A, Singh M. 2020
Low-dose liposomal amphotericin B for antifungal prophylaxis in paediatric allogeneic haematopoietic stem cell transplantation Natalia Mendoza-Palomar, Elena Soques, María Isabel Benitez-Carabante, Miriam Gonzalez-Amores, Aurora Fernandez-Polo, Berta Renedo, Maria Teresa Martin, Pere Soler-Palacin, Cristina Diaz-de-Heredia 2020
Aeroallergen sensitization in Lebanese asthmatic children: the results of a cohort national study Hala Feghali Abiad, Valeria Modica Alameddine, Souheil Hallit, Paul-Henry Torbey, Salman Mroueh, Nelly Yazbek, Edgard Asmar, Pierre Hage, George Abi Fares, Marie Samarani, Marie-Claude Fadous Khalife 2020
Characteristics of inner-city children with life-threatening asthma. Bollinger ME, Butz A, Tsoukleris M, Lewis-Land C, Mudd S, Morphew T. 2019
Prevalence and Risk Factors of Allergic Bronchopulmonary Aspergillosis and Aspergillus Sensitization in Children with Poorly Controlled Asthma. Kumari J, Jat KR, Lodha R, Jana M, Xess I, Kabra SK. 2020
Use of Micafungin for the Prevention and Treatment of Invasive Fungal Infections in Everyday Pediatric Care in France: Results of the MYRIADE Study. Leverger G, Timsit JF, Milpied N, Gachot B. 2019
Pulmonary acute graft versus host disease and infections after allogeneic hematopoietic stem cell transplantation in pediatric recipients:a comparative study on CT. Yan Y, Shi Y, Wang Y, Yuan X, He W. 2020
Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients. Lempers VJ, Meuwese E, Mavinkurve-Groothuis AM, Henriet S, van der Sluis IM, Hanff LM, Warris A, Koch BCP, Brüggemann RJ. 2019

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