Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.


Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.


Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.


This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 

Paediatrics

Pediatrics Fungal Infections

Displaying 1 - 10 of 203
Author year
Clinical features in proven and probable invasive fungal disease in children and adolescents at a pediatric referral center: a 5-year experience. Kishimoto K, Kasai M, Kawamura N, Ito Y, Yoshida M, Hasegawa D, Kawasaki K, Kosaka Y. 2019
International Collaborative on Contemporary Epidemiology and Diagnosis of Invasive Fungal Disease in Children. Steinbach WJ, Fisher BT. 2017
Diagnosis of Invasive Fungal Infections in Children. Seth R, Xess I, Jana M. 2019
A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia. Arrieta AC, Sung L, Bradley JS, Zwaan CM, Gates D, Waskin H, Carmelitano P, Groll AH, Lehrnbecher T, Mangin E, Joshi A, Kartsonis NA, Walsh TJ, Paschke A. 2019
Invasive Fungal Disease in Pediatric Acute Leukemia in the Nontransplant Setting: 8 Years' Experience From a Tertiary Care Center in North India. Das A, Oberoi S, Trehan A, Chakrabarti A, Bansal D, Saxena AK, Sodhi KS, Kakkar N, Srinivasan R. 2018
Posaconazole therapy in children with cystic fibrosis and Aspergillus-related lung disease. Patel D, Popple S, Claydon A, Modha DE, Gaillard EA. 2019
Micafungin prophylaxis in routine medical practice in adult and pediatric patients with hematological malignancy: a prospective, observational study in France. El Cheikh J, Ceballos P, Dalle JH, Ducastelle-Leprêtre S, Dulon E, Herbrecht R. 2019
Combination Antifungal Treatment for Invasive Fungal Disease After Hematopoietic Stem Cell Transplantation in Children with Hematological Disorders. Qiu KY, Liao XY, Fang JP, Xu HG, Li Y, Huang K, Zhou DH. 2019
Use of Micafungin for the Management of a Cluster of Invasive Aspergillosis in Children with Cancer Désirée Caselli, Luisa Galli, Annalisa Tondo, Daniela Cuzzubbo, Tommaso Casini, Lorena Di Simone, Angela Tamburini, Franco Bambi, Fabio Tucci, Maurizio Aricò 2019
Surgical management of pulmonary aspergillosis in pediatric population. AlShanafey S, AlMoosa N, Hussain B, AlHindi H. 2019

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