Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.

Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.

Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.

This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 


Pediatrics Fungal Infections

Displaying 1 - 10 of 233
Author year
Evaluation of target attainment of oral posaconazole suspension in immunocompromised children. Lai T, Alffenaar JW, Kesson A, Bandodkar S, Roberts JA. 2020
Isavuconazole use in pediatric patients with hemato-oncologic diseases and hematopoietic stem cell transplantation: a case-series and literature review. Decembrino N, Perruccio K, Zecca M, Colombini A, Calore E, Muggeo P, Soncini E, Comelli A, Molinaro M, Goffredo BM, De Gregori S, Giardini I, Scudeller L, Cesaro S. 2020
Need to re-look cut-off of Aspergillus-specific IgE levels in children with ABPA. Singh M, Chauhan A, Paul N, Jaiswal N, Singh S, Chakrabarti A, Singh M. 2019
A Retrospective Analysis of Invasive Fungal Diseases (IFD) of the Central Nervous System in Children With Lymphoid Malignancies. Ramanathan S, Kate S, Kembhavi S, Cheriyalinkal Parambil B, K C A, Bhat V, Prasad M, Moiyadi A, Biswas S, Narula G, Banavali S. 2019
Tacrolimus blood concentration increase depends on administration route when combined with voriconazole in pediatric stem cell transplant recipients. Utano T, Kato M, Osumi T, Shioda Y, Kiyotani C, Terashima K, Tomizawa D, Matsumoto K, Yamatani A. 2019
A phase I dose finding study of intravenous voriconazole in pediatric patients undergoing hematopoietic cell transplantation. Knight-Perry J, Jennissen C, Long SE, Hage S, DeFor TE, Chan WT, Fisher J, Kirstein MN, Smith AR. 2019
A consensus document for the clinical management of invasive fungal diseases in pediatric patients with hematologic cancer and/or undergoing hematopoietic stem cell transplantation in Brazilian medical centers. Carlesse F, Daudt LE, Seber A, Dutra ÁP, Melo ASA, Simões B, Macedo C, Bonfimi C, Benites E, Gregianin L, Batista MV, Abramczyk M, Tostes V, Lederman H, Lee MLM, Logetto S, Galvão C, Colombo AL. 2019
Factors Influencing the Safety and Efficiency of Antifungal Prophylaxis with Posaconazole in Children with Hematological Diseases: From Genetics to Polypharmacotherapy. Sienkiewicz-Oleszkiewicz B, Urbańczyk K, Stachowiak M, Rodziewicz A, Zięba A, Kałwak K, Wiela-Hojeńska A. 2019
Factors associated with all-cause mortality in pediatric invasive fungal rhinosinusitis. Alejandro A, de la Torre González C, Edgar M, Perla V. 2020
Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus. Vogel K, Pierau M, Arra A, Lampe K, Schlueter D, Arens C, Brunner-Weinzierl MC. 2018