Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.


Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.


Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.


This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Collected articles on pediatric fungal infections (Searchable)

Computed content type (Paediatrics): 

Paediatrics

Pediatrics Fungal Infections

Displaying 1 - 10 of 217
Author year
Combination antifungal treatment for invasive fungal disease after hematopoietic stem cell transplantation in children with hematological disorders. Qiu KY, Liao XY, Fang JP, Xu HG, Li Y, Huang K, Zhou DH. 2019
Plasma exposures following posaconazole delayed-release tablets in immunocompromised children and adolescents Athanasios Tragiannidis, Heidrun Herbrüggen, Martina Ahlmann, Eleni Vasileiou, Silke Gastine, Heike Thorer, Birgit Fröhlich, Carsten Müller, Andreas H Groll 2019
Invasive fungal infections in children with acute lymphoblastic leukaemia: Results from four Australian centres, 2003-2013. Wang SS, Kotecha RS, Bernard A, Blyth CC, McMullan BJ, Cann MP, Yeoh DK, Bartlett AW, Ryan AL, Moore AS, Bryant PA, Clark J, Haeusler GM. 2019
Frequency of the CYP2C19*17 polymorphism in a Chilean population and its effect on voriconazole plasma concentration in immunocompromised children. Espinoza N, Galdames J, Navea D, Farfán MJ, Salas C. 2019
Clinical practice update of antifungal prophylaxis in immunocompromised children. Ramos JT, Romero CA, Belda S, Candel FJ, Carazo Gallego B, Fernández-Polo A, Ferreras Antolín L, Garrido Colino C, Navarro ML, Neth O, Olbrich P, Rincón-López E, Ruiz Contreras J, Soler-Palacín P; Fungal Infection Study Group of Spanish Society of Paediatric Infectious Disease (SEIP); Traslational Research Network in Pediatric Infectious Diseases (RITIP).. 2019
Opportunistic fungal infection in children and management. Lam JM 2018
Diagnosis of Invasive Fungal Infection Among Pediatric Oncology Patients. Hodgman EI, Compton , Qureshi FG, Murphy JT. 2019
Infectious complications in children with malignant bone tumors: a multicenter nationwide study. Czyzewski K, Galazka P, Zalas-Wiecek P, Gryniewicz-Kwiatkowska O, Gietka A, Semczuk K, Chelmecka-Wiktorczyk L, Zak I, Salamonowicz M, Fraczkiewicz J, Zajac-Spychala O, Bien E, Plonowski M, Wawrykow P, Pierlejewski F, Gamrot Z, Malas Z, Stolpa W, Musial J, Styczynski J. 2019
Management of Invasive Fungal Disease in Neonates and Children. Ferreras-Antolín L, Sharland M, Warris A. 2019
Plasma exposures following posaconazole delayed-release tablets in immunocompromised children and adolescents Athanasios Tragiannidis, Heidrun Herbrüggen, Martina Ahlmann, Eleni Vasileiou, Silke Gastine, Heike Thorer, Birgit Fröhlich, Carsten Müller and Andreas H Groll 2019

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