New antifungals drugs, new approaches and vaccines

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Title Antifungal name Trial phase Date
The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis EV-086 10 Oct 2014
Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans Icofungipen (PLD-118) 10 Oct 2004
In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans Icofungipen (PLD-118) 10 Oct 2017
Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits Icofungipen (PLD-118) 10 Oct 2005
Sampangine (a Copyrine Alkaloid) Exerts Biological Activities through Cellular Redox Cycling of Its Quinone and Semiquinone Intermediates Sampangine 24 Dec 2015
Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine Sampangine 10 Oct 2008
Myriocin, a new antifungal antibiotic from Myriococcum albomyces Myriocin 10 Oct 1972
Inhibition of ceramide de novo synthesis by myriocin produces the double effect of reducing pathological inflammation and exerting antifungal activity against A. fumigatus airways infection Myriocin 10 Oct 2016
Antifungal activity of Myriocin on clinically relevant Aspergillus fumigatus strains producing biofilm 30 Oct 2015
Drugs in Clinical Development for Fungal Infections (review includes CD101) CD101 5 Oct 2017