New antifungals drugs, new approaches and vaccines

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Title Antifungal name Trial phase Date
Growth inhibition of Candida species and Aspergillus fumigatus by statins. Statins 19 Sep 2006
Efficacy and tolerability of amorolfine 5% nail lacquer in combination with systemic antifungal agents for onychomycosis: A meta-analysis and systematic review Amorolfine Phase 2 9 May 2017
Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis Amorolfine 9 Sep 2017
Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin H Ilicicolin H 7 Sep 2012
Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis KOSN-2079 (polyketide) 17 Oct 2006
Antifungal activities of R-135853, a sordarin derivative, in experimental candidiasis in mice R-135853 19 Jan 2005
In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections SM21 22 Jan 2014
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids BHBM 23 Jun 2015
Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans FK506 (tacrolimus) and L-685,818 23 Mar 2000
Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei Tacrolimus 19 Mar 2003