New antifungals drugs, new approaches and vaccines

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Title Antifungal name Trial phase Datesort ascending
Open-Label Study to Evaluate Efficacy and Safety of SCY-078 in Patients With Refractory or Intolerant Fungal Diseases (FURI) Ibrexafungerp (SCY-078, MK-3118) Phase 3 1 Apr 2017
Pharmacokinetics of the Novel Echinocandin, CD101, in Multiple Animal Species. Biafungin (CD101) 27 Mar 2017
Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis. Ibrexafungerp (SCY-078, MK-3118) Phase 2 27 Mar 2017
In vitro and in vivo antifungal profile of a novel and long acting inhaled azole, PC945, on Aspergillus fumigatus infection. PC945 13 Mar 2017
Trans-ungual Delivery of AR-12, a Novel Antifungal Drug. AR-12 13 Mar 2017
Activity of a Long-Acting Echinocandin (CD101) and Seven Comparator Antifungal Agents Tested Against a Global Collection of Contemporary Invasive Fungal Isolates in the SENTRY (2014) Antifungal Surveillance Program. Biafungin (CD101) 15 Feb 2017
Special Issue: Novel Antifungal Drug Discovery General articles 15 Feb 2017
ram1 gene, encoding a subunit of farnesyltransferase, contributes to growth, antifungal susceptibility to amphotericin B of Aspergillus fumigatus. Manumycin A 4 Feb 2017
Structure-Activity Relationships of a Series of Echinocandins and the Discovery of CD101, a Highly Stable and Soluble Echinocandin with Distinctive Pharmacokinetic Properties. Biafungin (CD101) 23 Jan 2017
Safety and Pharmacokinetics of CD101 IV, a Novel Echinocandin, in Healthy Adults. Biafungin (CD101) 23 Jan 2017