LIVING WITH IT WORKING WITH IT TREATING IT
If you have ever had athlete's foot or a yeast infection, you can blame a fungus. A fungus is a primitive organism. Mushrooms, mold and mildew are examples. Fungi live in air, in soil, on plants and in water. Some live in the human body. Only about half of all types of fungi are harmful.
Some fungi reproduce through tiny spores in the air. You can inhale the spores or they can land on you. As a result, fungal infections often start in the lungs or on the skin. You are more likely to get a fungal infection if you have a weakened immune system or take antibiotics.
Fungi can be difficult to kill. For skin and nail infections, you can apply medicine directly to the infected area. Oral antifungal medicines are also available for serious infections.
A new online version of the 4th edition is now available!
It will allow fast and very comfortable search through the entire Atlas text. The engine is fully equipped for title as well as for general search. Items are strongly linked, enabling direct use of the electronic version as a benchtool for identification and comparison. Text boxes with concise definitions appear, explaining all terminology while reading. The fourth edition will contain nearly 600 clinically relevant species, following all major developments in fungal diagnostics. Regular updates of the Atlas are planned, which should include numerous references to case reports, as well as expanded data on antifungals.
The currently used identification methods of agents causing human mycoses have serious limitations, are time consuming and require special trained personal. However to enable an informed choice for proper anti-fungal treatment an adequate identification at the specific level is necessary. DNA sequencing is an alternative to classical fungal identification. The Internal Transcribed Spacer (ITS) regions of the ribosomal DNA gene cluster is now widely used in clinical laboratories for fungal species identification. We have generated quality controlled ITS sequence data representing the actual sequence variation found in a species.
Thanks to eleven contributing research groups from all around the world the database currently contains more than 3200 sequences representing 524 human/animal pathogenic fungal species. Users are encouraged to submit their full dataset to the curators of the database, to enable the build up of comprehensive global ITS database of clinically important fungal pathogens.
A personal blog by Canadian microbiologist 'Yuri' containing many years worth of high quality images of microbial subjects (macroscopic and microscopic), including many fungi and of course Aspergillus.
Roger Phillips' twenty-year study makes this site the most complete collection of photographs and mushroom information from both sides of the Atlantic ever assembled. We already have over 3000 images on our site to help you identify and learn more about the mushrooms of Europe and North America! RogersMushrooms is now completely free to access!
Website of the Fungal Cell Biology Group at the University of Edinburgh. The main focus of research is on developmental pathways resulting from conidial germination and the early stages of colony establishment in the fungal model Neurospora crassa and the human pathogen Aspergillus fumigatus. Much of the research involves analysing living cells using a wide range of advanced imaging and measurement techniques and the site is superbly illustrated with video and photographic results of these analyses.
You should be able to find everything you wanted to know about fungi by clicking on the on the links on the images or on the text links. Tom promises to leave his pages at this site for a long time, and points out that you can always find them by typing (no spaces) into your browser.
BEI Resources was established by the National Institute of Allergy and Infectious Diseases (NIAID) to provide reagents, tools and information for studying Category A, B, and C priority pathogens, emerging infectious diseaseagents, non-pathogenic microbes and other microbiological materials of relevance to the research community. BEI Resources acquires authenticates, and produces reagents that scientists need to carry out basic research and develop improved diagnostic tests, vaccines, and therapies. By centralizing these functions within BEI Resources, access to and use of these materials in the scientific community is monitored and quality control of the reagents is assured.
In addition to supplying the infectious disease community with materials, BEI Resources also encourages and supports the deposit of materials from researchers and institutions. Depositing materials with BEI Resources has many advantages to the researcher and the research community including secure storage, community access and distribution; all while protecting the intellectual property rights of the depositor. The BEI Resources repository will be maintained as a resource for researchers as long as there is need. Your deposit into BEI Resources is a long term investment to aid future research.
BEI Resources has been managed under contract by American Type Culture Collection(ATCC) since 2003. A seven-year contract to continue managing BEI Resources was awarded to ATCC in June 2010. The scope of the contract expanded in 2010 to a more comprehensive catalog of research materials, including those deposited by other Government-supported research projects, to be made available to the biodefense and emerging infectious disease scientific communities. Fungal, Parasite, Vector and other relevant Materials have been added to the existing Bacterial, Viral and Toxin reagents which cover NIAID Category A, B and C Priority Pathogens and NIAID designated emerging infectious disease agents and organisms. The BEI Resources program reflects a coordinated effort between NIAID, CDC, USDA, and ATCC.
You can search our catalog of reagents for a list of items in our current catalog. Materials from the Department of Defense Critical Reagents Program (CRP) may also be requested through BEI Resources. Scientists must be registered with BEI Resources to request materials.
承蒙遠東及香港區共濟會之菲裘新研究東亞學科基金的贊助，使這部以中文介紹真菌生理、生化、遺傳、細胞學、發育和形態的資料可出版，著者深致謝意! 特別鳴謝W. Bro. Peter J. Nunn 的支持。
The authors are deeply grateful to The Freemasons’ Fund for East Asian Studies by the District Grand Lodge of Hong Kong and the Far East, without which this publication would not have been possible. We are especially grateful to Mr. W. Bro. Peter J. Nunn, District Grand Secretary of the Fund for the kind support. Recently there have been a few mycology books been published. The information is overwhelming. In order to give a precise and concise introduction on fungal morphogenesis, the authors adopt an illustrative approach. In this webpage, relevant mycological websites is included for the readers to update information resource and/or participate in discussion forum.
This is an interactive website of general fungal biology that covers the whole range of mycology
Chinese traditional medicine uses a variety of natural products to treat illness, many of which have no sound medical reasoning. In this study I am to assess the evidence for and against the use of a particular fungus called Cordyceps chinensis, to determine whether or not there is any hard science to its curative effect or whether it is just blind faith. I found some promising material on the effects of the fungus especially in the use of athletics where field tests have been performed. The problems encountered were the reliability of the claims. This was because of where the information was gathered e.g. internet and Chinese journals, where we have to be a little sceptical whether the tests and reports have been properly monitored and checked. In conclusion I found that the use of this fungus medically seems bright but more controlled investigations need to be performed, especially in the West to dispel the myths about traditional chinese medicine.
My name is Jonathan Dixon and as a final year undergraduate student at the University of Manchester (UK) in 2001 I designed the original version of this website on Fungal Evolution for my final year project. It has been updated in 2011 and is primarily aimed at undergraduates in biological sciences, but anyone with a keen interest in fungi may find it useful and appealing. I decided to split the topic of fungal evolution into three main headings, however there is no order or dominance to any one grouping, so you can view them as you wish. They are:
Kingdom Fungi: This section briefly describes whereabouts fungi lies in the six kingdoms of life. It includes descriptions of all kingdoms, emphasizing, of course, on the broad definition of fungi.
Diversification: The kingdom fungi is split into 4 main phyla. This section includes knowledge regarding these phyla, as well as information on those organisms that have one time or another been confused with fungi.
Origins of fungi: Under this heading you will find information regarding the actual times of fungi divergence and the methods involved to find out such evolutionary dates.
You will also find useful bibliography, links and glossary pages.
Discovery of cyclosporine in 1971 began a new era in immunopharmacology. It was the first immunosuppressive drug that allowed selective immunoregulation of T cells without excessive toxicity. Cyclosporine was isolated from the fungus Tolypocladium inflatum. Cyclosporine was first investigated as an anti-fungal antibiotic but its spectrum was too narrow to be of any clinical use. J. F. Borel discovered its immunosuppressive activity in 1976. This led to further investigations into its properties involving further immunological tests and investigations into its structure and synthesis. Cyclosporine has unwanted side effects, notably nephrotoxicity. Animal testing showed cyclosporin to be sufficiently non-toxic to begin clinical trials. These initially failed due to poor absorption of the drug. Once this had been overcome, results were encouraging enough for cyclosporine to be licensed for use in clinical practice. There is some controversy between Borel and other workers over priority in the discovery of cyclosporine and its pre-clinical development, which is examined in this review. Cyclosporine changed the face of transplantation. It decreased morbidity and enabled the routine transplantation of organs that until then had only been done experimentally.
Research on Ganoderma is briefly reviewed. The mushroom’s antitumour, cardiovascular, immunomodulatory and anti-HIV effects were critically evaluated. Each paper read was partly judged on the reliability of the journal in which it was published; so-called "impact factors" being used as a measure of credibility.
Theoretical evidence raises the possibility that Ganoderma does have medicinal potential, however there is a lack of reliable clinical evidence to support this.
The discovery of Diflucan (fluconazole) was a major landmark in the pharmaceutical industry, as it was the first antifungal drug to be developed that could be used both orally, for minor infections such as candidiasis, or intravenously for more serious systemic infection like cryptococccal meningitis.
Fluconazole development was based on two initial assumptions by the scientists involved: firstly that drugs should be tested in experimental models of infections, and secondly that a polar molecule might have superior pharmacological properties. The developers took these two ideas as a starting point and went through a rigorous process to find the right compound. Eventually they came across 2-(2,4-difluorophenyl)-1,3-bis (1H-1,2,4-triazol-1-yl)-2-propanol, that is fluconazole. This report details the progressive discovery of fluconazole and all the intermediate steps and compounds found along the way. The report also describes the general development of drugs, the history of antifungal agents of the past and examines the major agents currently available. There is also a section devoted to the clinical and pharmacological profile of fluconazole, and any considerations concerning the future development of antifungal agents.
The medicinal value of shiitake is not really well appreciated in Western medicine, though it has a long history as a valuable remedy in traditional Asian medicine. Research on the chemicals present in Lentinula edodes seems to be revealing medical products and it may become a valuable resource in fighting diseases.
Fungi for better health and environment [downloads a PDF presentation showing an overview of fungi, their place in the natural world and impact on human affairs.]
Ergot is a fungal infection that has infected rye and other plants since farming began. One of the constituents of ergot, the ergot alkaloids, were found to have useful medicinal properties. Ergot was known to cause gangrene in the limbs of those who had ingested infected bread. But later its first medicinal property as a powerful oxytocic (facilitating childbirth) was discovered, and more recently its derivatives have been used in the treatments of migraine. It was the alkaloids of ergot that were found to be the active components in their pharmacological actions, starting with the first pure alkaloid to be isolated, ergotamine. This review covers the history of ergot and the ergot alkaloids and tries to show how ergot went from being just an infection of grass to its alkaloids being the active component in many drugs, especially those in the treatment of migraine. The mechanism of action of the ergot alkaloids is also explained.
Traditional Chinese medicine (TCM) uses many products derived from fungi, including Lentinula edodes (shiitake). Evidence, in the form of published papers, regarding its usefulness has been examined. The review finds that the anti-tumour claims are substantiated, especially those of the lentinan polysaccharide isolated from shiitake. Lentinan is also found to be an immunomodulator, although the medicinal value of these findings are yet to be reliably established. Cholesteremic effects were shown but there was disagreement over the details of the effects. It was concluded that Lentinula edodes does have much potential in medicine but further research is needed.
Ask about fungi and people think about fine specimens like these guys:
Ask to what they are related and you'll probably find that some people think fungi are plants...others think they might be bacteria.
‘How many of you think that fungi are bacteria?’ is a question posed at a recent Summer School for year 10 pupils (4th year in secondary school, and about 16 years of age at the time), by one of the pupils who had attended a workshop session of ours. When all attendees (approximately 170 pupils) were asked 'Hands up all those who think fungi are plants', about 15 hands went up, but when asked 'Hands up all those who think fungi are bacteria', at least 150 hands went up!
As teachers we are used to battling against the mistaken idea that fungi are plants, but it was a shock to find that so many pupils believe that fungi are bacteria so close to the end of their statutory education. After all, it’s a bigger error than for them to think that whales are fish; at least whales and fish are in the same biological Kingdom. Does such ignorance matter? We say it does. The practical reason it matters is because the activities of fungi are crucially important in our every day lives. The educational reason it matters is that fungi form what is arguably the largest kingdom of higher organisms on the planet. Ignorance of this kingdom is a major blot on our personal education.
Fungi are not bacteria, because fungi are eukaryotes and they have the complex cell structures and abilities to make tissues and organs that we expect of higher organisms.
The story of the statin based drugs provides an interesting insight into the discovery and development of modern pharmaceuticals. As well as looking at the complexity of the technology and science involved, this Special Studies Module also looks at the time and resources that must be devoted to developing a marketable drug from an initial concept. Whilst the pharmacology of a specific family of drugs might be similar, small differences in molecular composition, and human physiology can substantially alter the overall effectiveness of the drug, and even classes of patient in which the drug might be of use.
Given the cost of development, many drugs will become unaffordable to a large proportion of the world population, even if the cost seems reasonable in terms of suffering and the palliative care that might have to be offered in their place. The problem of cost may also be exasperated as the development and marketing of new drugs often seems to be in the control of a handful of large multinational companies.
Fungi have been influencing human affairs for thousands of years, whether as a direct food source, as a medicine, or in a food process . Today food of fungal origin is consumed all over the world in vast quantities, and commercial production is part of a rapidly growing industry. Fungi are of excellent value nutritionally, and of great importance to vegetarians. Edible mushrooms have high protein content, and are an excellent source of fibre, vitamins, and some minerals. Efforts to combat anticipated world food shortages, led to the production of ‘single cell protein’, grown in industrial fermenters using yeast cells. The result is a protein extract with high amino acid content potentially favourable for use in human nutrition. One particularly successful model was that of myco-protein, marketed as Quorn™. Essentially the mycelium of Fusarium venenatum, its filamentous nature much resembles the fibres of meat. Quorn is now available in supermarkets, marketed as a high-protein, low-fat, cholesterol-free ‘meat alternative’. When it comes to fungi as a food source, many people are apprehensive and much education is needed before the true nutritional value of such a cheap, readily available food source can be fully realised.
Our use of fungi is usually hidden from view, so the way we most often directly encounter useful fungi is as part of a meal of mushrooms!
All photographs © David Moore 2011
Mushroom cultivation is important, and I will say more about it below, but it's not the only way we can and do make use of fungi.
Microbiology online has been devised by the Microbiology Society, the largest learned microbiological society in Europe. This inspirational online resource supports the teaching and learning of microbiology in the classroom across the key stages. It explores how microbes can be friend and foe and most importantly, why we need these invisible organisms to live.
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