Postdoctoral Research Fellow


Summary of the role/position

The Vyas Laboratory seeks a Postdoctoral Research Fellow to join our team at the Massachusetts General Hospital/Harvard Medical School in Boston, Massachusetts in the Division of Infectious Diseases.

Our laboratory focuses on how our body responds to fungal pathogens. Invasive fungal infections are a leading killer of patients with compromised immune systems (usually from cancer or being a recipient of a transplant). To investigate fungal immunology, our lab applies novel imaging modalities, including optical traps and live cell imaging, as well as genetic murine models to elucidate the molecular basis of recognition of pathogenic yeast by immune cells. Our work has demonstrated that specific recruitment of mammalian proteins to phagosomes depends on its content and potently modulates the ensuing immune response. Our current projects focus on the role of the type I interferon signalling pathway as well as the tetraspanin CD82 in host defence against fungal pathogens. We are also interested in the role of the lung epithelium in shaping the ensuing immune response.

The successful applicant will join an NIH-funded research program to define how the innate immune system responds to fungal pathogens. This position provides outstanding opportunities that support scientific development and career growth.

Principal Duties and Responsibilities:

• Develop their ideas with Dr. Jay Vyas for their own research project

• Perform data collection and properly analyze results

• Collaborate effectively with other members of the Vyas lab

• Prepare and submit manuscripts of their work for publication

• Present their work at conferences

• Integrate with collaborators at MGH and outside institutes

• Contribute to the activities of MGH (e.g. research and outreach).

• Train and mentor lab colleagues

• Participate in weekly lab meetings


Applicants should possess a relevant PhD (or be nearing completion) or an equivalent qualification/experience in microbiology, immunology, or a related discipline. They should be able to demonstrate sufficient knowledge in the discipline, research methods, and techniques to work within established research program. Applicants should be able to provide two professional letters of reference upon request.

Skills and Competencies

• Demonstrated record of performing independent research

• Knowledge of MS Office applications and reference software (e.g. EndNote)

• Knowledge of relevant analysis software (e.g. GraphPad Prism, FlowJo, ImageJ)

• Strong written and verbal communication skills

• A proven ability to work both independently and collaboratively

• Ability to adapt to shifting priorities in response to changing deadlines and the needs of the lab

• Excellent organizational skills

• Sterile cell culturing techniques (desired, but not required)

• Experience in imaging modalities (desired, but not required)

• Experience with animal models of infections (desired, but not required)

Closing date: 30 September 2020

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