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Medium power microscopy of H&E strained mucus plug Microscopy of a fungal plug
Medium power microscopy of H&E strained mucus plug Microscopy of a fungal plug

ABPA plug stained with H&E showing many eosinophils surrounded by myelin basic protein (intense pink) and neutrophils within amorphous mucus.

High power microscopy of GMS strained mucus plug Microscopy of a fungal plug
High power microscopy of GMS strained mucus plug Microscopy of a fungal plug

Higher power GMS stain showing Aspergillus hyphae surrounded by amorphous material characteristic of an ABPA mucous plug.

Medium power microscopy of GMS strained mucus plug Microscopy of a fungal plug
Medium power microscopy of GMS strained mucus plug Microscopy of a fungal plug

Medium power GMS stain showing dark staining fragmented  hyphae scattered within an ABPA mucous plug.

Low power microscopy of GMS strained mucus plug Microscopy of a fungal plug
Low power microscopy of GMS strained mucus plug Microscopy of a fungal plug

Low power GMS stain showing fragmented dichotomously branching hyphae scattered with an ABPA mucous plug.

Homeopathic remedy A bottle of homeopathic pills intended to treat aspergillosis.
Homeopathic remedy A bottle of homeopathic pills intended to treat aspergillosis.

A bottle of homeopathic pills intended to treat aspergillosis.

Fungal ball A fungal ball, or plug, coughed up by a patient.
Fungal ball A fungal ball, or plug, coughed up by a patient.

A fungal ball, or plug, coughed up by a patient.

Removal of fungal ball from maxillary sinus: Image A, Image B, Image C
Image A, Image B, Image C Removal of fungal ball from maxillary sinus:

CT scans: This patient had bilateral extensive fungal rhinosinusitis caused by bipolaris spicifera. See video clip

Ref: Clin Microbiol. 2003 October; 41(10): 4885–4887 (With permission of Dr Walter Buzina, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical School, Graz, Austria)

A. Coronal section, showing eye, maxillary sinus, beneath the eye the nasal cavity is swollen and full of mucosa and nasal polyps.

B. Sagittal section- scan shows nasal polyps extending into the erythmoidal sinuses

C. Endoscopy view of left nasal passage.

Guido Pontecorvo, 1907-1999 Guido Pontecorvo, 1907-1999
Harry Marshall Ward, 1854-1906 Harry Marshall Ward, 1854-1906
Philip Montagu D'Arcy Hart, 1900 - 2006 Philip Montagu D'Arcy Hart, 1900 - 2006, Philip Montagu D'Arcy Hart, 1900 - 2006
Raimond Sabouraud, 1864 - 1938 Raimond Sabouraud, 1864 - 1938, Raimond Sabouraud, 1864 - 1938, Raimond Sabouraud, 1864 - 1938
Raimond Sabouraud, 1864 - 1938, Raimond Sabouraud, 1864 - 1938, Raimond Sabouraud, 1864 - 1938 Raimond Sabouraud, 1864 - 1938

In addition to being a worldwide known mycologist, Sabouraud was a talented painter and sculptor. Short biography and bibliography of Sabouraud

The outstanding names in the history of any branch of science are not always those of the men who made the primary observation. The prevailing climate of opinion and the available techniques greatly affect the contemporary significance attributed to any novel discovery and the historical land marks are frequently the reputations of subsequent workers who were men of their time, who showed singleness of purpose and who crystallise ideas which were nearing supersaturation. Raimond Sabauroud the French Dermatologist, was such a man. In the early 1890's by remaking observations which had been on record for fifty years but not universally accepted, he was able to silence finally the view that the association of fungi with ringworm was incidental.
Using the recently developed pure culture techniques he was able to establish convincingly the plurality of the ringworm fungi, and his medical training enabled him to integrate the mycological and clinical aspects of ringworm. He was stimulated by the advances made by able contemporaries in both medicine and veterinary science and finally in 1910 he codified both his own and their results in the monumental Les Teignes, one of the most comprehensive treatments ever given to a group of pathogenic fungi and a monograph to which students of the dermataophytes must still refer.
The dermatomycoses have always been a basic theme of medical and veterinary mycology and at the turn of the century they overshadowed the systemic mycoses by which the dermatomycoses are overshadowed today. They served to focus attention on fungi as pathogens of man and higher animals and provided a seed from which an interesting branch of medicine and vet science has emerged.

From Sabouraudia vol 1 1961-2 p1 by GC Ainsworth

JAMES CLARK GENTLES, 1921 - 1997 JAMES CLARK GENTLES, 1921 - 1997
Jack Pepys, 1914 - 1996 Jack Pepys, 1914 - 1996
Rudolf Virchow, 1821-1902 Rudolf Virchow, 1821-1902, Rudolf Virchow, 1821-1902, Rudolf Virchow, 1821-1902
Rudolf Virchow, 1821-1902, Rudolf Virchow, 1821-1902, Rudolf Virchow, 1821-1902 Rudolf Virchow, 1821-1902

Rudolf and Rose Virchow

To view images from his publication "A case of Aspergillosis" in Arch. path. Anat. 9 (1856) 557 –593) click here to see a PDF containing these images.

Libero Ajello, 1916 - 2004 Libero Ajello, 1916 - 2004

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