Zygomycosis at a multispecialty center: our experience

Ranjeeta Adhikarv*. Sangeeta Joshi, Bhavana MV, and Beena HB

Author address: 

Manipal Hospital, HAL Airport road. Bangalore - 560 017

Abstract: 

Invasive zygomycosis is an aggressive and opportunistic fungal infection with a high morbidity and mortality rate. It predominantly affects immunosuppressed patients. Presented here in is our investigation of the disease at a multispecialty centre in South India, over the past four and a half years. This was a retrospective study of the clinical charts and microbiology records of patients with a positive culture for zygomycetes, to analyze sites of involvement, underlying disease, species of fungi isolated, type of antifungal used in treatment and clinical outcome. A total of ten patients with proven zygomycetes infections were identified from January 2009 to August 2013. All cases were unrelated and no hospital acquired source of exposure or seasonal aggregation were identified. Rhino-orbital-cerebral type (80%) was the commonest presentation. Uncontrolled diabetes mellitus was the significant risk factor in all cases. The species isolated were Rhizopus arrhizus (4 patients), Rhizomucor pussilus (2 patients), Rhizomucor sp. (2 patients), Apophysomyces elegans (1 patient) and Mucor sp. (1 patient). Two patients had dual infection of Aspergillus flavus and C. tropicalis with zygomycetes. All patients were managed with amphotericin B. Three patients had fatal outcome. The follow up history of one patient could not be obtained as he was discharged against medical advice. This study supports previous research and highlights the importance of increased awareness for early diagnosis of zygomycosis, especially in uncontrolled diabetes and immunosuppressed patients and the need for a rapid initiation of an effective antifungal treatment. 9830;Corresponding author E-mail: [email protected]
2014

abstract No: 

OP-026

Full conference title: 

Society for Indian Human and Animal Mycologists 2014
    • SIHAM