What are the infections which increase mortality after allogeneic stem cell transplantation? Results of a prospective scoring system used in 190 consecutive patients

C. Cordonnier, S. Maury, P. Ribaud, M. Kuentz, M. Legrand, F. Bassompierre, E. Gluckman, S. Chevret

Author address: 

Hôpital Henri Mondor, Hôpital Saint Louis, Direction Régionale de la Recherche Clinique, DBIM Hopital Saint Louis (Creteil, Paris, F)


Objectives: For the purpose of a prospective study on the benefit of prophylactic immunoglobulins in allogeneic HLA-identical sibling SCT (1), we elaborated a scoring system to assess the severity of the infections occurring after according to the expected rate of mortality in the literature. The aim of the present study is to assess the relationship between the severity of each infection, and the mortality process. Patients and Methods: 440 infectious events occurring within 6 months after transplant were prospectively collected and graded in 190 consecutive patients. 77% patients were leukemic. The median age was 40 y. All received myelo-ablative transplants.  The infections were graded as follows: Infections of grade 1 were those usually treated at home (including asymptomatic CMV infection) or  febrile neutropenia of unknown origin treated with broad-spectrum antibiotics. Infections of grade 3 were those with an expected mortality rate 60% (i.e., bacteremia or fungemia with severe sepsis, aspergillosis, CMV disease, pneumonia with an initial PaO2

abstract No: 


Full conference title: 

30th Annual Meeting of the European Group for Blood and Marrow Transplantation
    • EBMT 2004