In vitro susceptibility of bloodstream Candida spp. to voriconazole

Cantón, E. , J. Pemán, A. Viudes, P. Tallón, M.C. Peñalver, J. Frasquet, M. Gobernado (Valencia, E)


Background: The increased use of antifungal agents for prophylaxis in immunodepressed patients has resulted in a decreased susceptibility of yeast to azoles. Voriconazole (VZ) is a novel broad spectrum triazole active against yeast and many filamentous fungi. Objective: To determine the susceptibility of yeast strains isolated from blood to VZ and compare with that of fluconazole (FZ) and itraconazole (IZ). Material and Methods: A total of 131 yeast strains (48 C.albicans, 31 C.parapsilosis, 14 C.krusei, 16 C.tropicalis, 13 C.glabrata, and 10 miscellaneous yeast species) isolated in 1998 and 1999 were tested by the M27-A microdilution method using a visual reading performed after 48h of incubation. Results: The range of MICs of VZ was 2 mg/l for C.albicans and C.parapsilosis and the geometric mean MIC (GM MIC) was 0.007 and 0.013 mg/l, respectively. C.krusei, C.tropicalis, and C.glabrata were less susceptible with a range of MICs/GM MIC from 2 to 0.25/0.7, 2 to 0.03/0.14 and from 2 to 0.06/0.68 mg/l, respectively. For the miscellaneous group the VZ range was 0.12 to 2mg/l of VZ were resistant to IZ (MIC >4mg/l). Two strains of C.albicans resistant to FZ (MIC >64mg/l) were susceptible to VZ (MIC

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11th European Congress of Clinical Microbiology and Infectious Diseases
    • ECCMID 11th (2001)