Objective: To determine the in vitro activity of human colostrums against common neonatal bacterial blood isolates versus commonly used broad spectrum antimicrobials Significance: The current concept of the antimicrobial activity of human colostrum against common nursery isolates as compared to selected broad spectrum alltimicrobials is validated. Study Design: In vitro mltibiotic susceptibility testing of reference strains versus that of colostrum Setting: Obstetric ward at a tertiary private hospital Population: Twenty mothers delivered from October until November 2004 who fulfilled tile inclusion criteria Methodology: Colostrum of twenty healthy mothers of teml neonates on their first three days was collected by steiile mmmal expression. Samples were analyzed for in vitro antimicrobial activity against reference strains of Escherichia toll, Pseudomonas aeruginosa, Klebsiella Fneumoniae and Staphylococcus aureus; and to compare the antimicrobial activity of colostrum with tile most commonly used antimicrobials for a specific microorgmtisms based on zone of inttibition. Results: /n vitro antimicrobial activity of colostrum against tile four microorganisms using the Mueller Hinton Agar based on zones of inhibi tion showed in this study that 70% of Klebsiella and E. toll, and 55% of Staphylococcus aureus were resistant to colostrum. On the other hand, only 5% of Pseudomorms showed lesistance to colostrums and ttighest 95% intermediate activity. Comparing colostrum with some broad spectrum antimicrobials for specific microol~galtisms: for E. coli, colostrum had inferior antimicrobial activity compared to that ampicillin sulbactam and ampicillin. Likewise for Klebsiella, it has inferior activity to ceftazidime, piperacillin tazobactam. For Pseudomonas, it has inferior activity to cef tazidime, piperacillin-tazobactam, anfikacin; and for Staphylococcus, it is itfferior to oxacillin and cefuroxime. Cmldusion: Tkis study showed that colostrum has tile ttighest antibacterial activity at intermediate level against Pseudomorms as compared to Klebsiella, E coli and Staphylococcus aureus; and none of these four pathogens was shown to be sensitive to colostrnm. Colostrum as compared with commonly used antibiotics is generally inferior in its activity for a specific microm~ganisms. Colostrum cannot replace antibiotics in fighting bacterial infection, such as those due to Pseudomorms. However, its use in newborns can minimize tile risk of infections or can decrease tile mortality or risk of death. This finding holds promise as another tool to augment the use of the antibacterial effect of standard antibiotics.
Full conference title:
International Congress on Chemotherapy, 24th Meeting
- ICC 24 th