In Vitro Antifungal Activity of V-253, against Different Fungi

Jose A. Vazquez, Dina Boikov, Victor Tez

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Background: The in-vitro antifungal activity of V-253, a new class of synthetic chemical compounds (derivative of arylidenimino-1,3-pyrimidines) possessing a wide spectrum of biological activities was evaluated against 40 strains of Candida, (5) Saccharomyces cerevisiae, (5) Geotrichum candidum, (5) Aspergillus spp., and (5) Mucor spp. Including strains with known azole resistance. Methodology: In-vitro evaluation was performed, and compared to fluconazole and amphotericin B using NCCLS microbroth dilution and read at 48 hrs. Results: The minimal inhibitory concentration (MIC50/MLC) of V-253 for C. albicans was 64/64 μ g/ml, C. glabrata 32/32 μ g/ml, C. tropicalis 32/64 μ g/ml, C. parapsilosis 2/32 μ g/ml, C. lusitaniae 8/8 μ g/ml, C. dubliniensis 32/64 μ g/ml, C. stellatoidea 2/4 μ g/ml, C. krusei 16/16 μ g/ml, S. cerevisiae 4/8 μ g/ml, G. candidum 8/8 μ g/ml, Mucor spp. 4/8 μ g/ml, Aspergillus spp. 64/64 μ g/ml. Conclusions: The results indicate that V-253 demonstrated the best activity with the lowest MICs against C. parapsilosis, C. stellatoidea, S. cerevisiae, and Mucor spp., less activity against C. lusitaniae, G. candidum , C. krusei, and C. dubliniensis, and the least activity against C. glabrata, C. tropicalis, C. albicans and Aspergillus spp. In addition, V-253 demonstrated fungicidal activity as demonstrated by MLC for most of the isolates evaluated except for C. parapsilosis. Overall, V-253 demonstrated a broad spectrum of activity with good activity against numerous Candida spp. and Mucor spp.

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Full conference title: 

    • ICAAC 42nd