Visceral leishmaniasis during childhood in southern Greece

Maltezou, H. C.;Siafas, C.;Mavrikou, M.;Spyridis, P.;Stavrinadis, C.;Karpathios, T.;Kafetzis, D. A.

Author address: 

Kafetzis, DA, Univ Athens, P&A Kyriakou Childrens Hosp, Dept Pediat 2, GR-11527 Athens, Greece

Abstract: 

Records were reviewed of 82 immunocompetent children (median age, 2.5 years) from southern Greece who were diagnosed with visceral leishmaniasis from 1986 through 1998. Forty-nine (58%) patients originated from the city of Athens; of them, 46 (94%) lived by hills bordering the city. The median interval from the onset of symptoms to admission was 10 days. Fever and splenomegaly were observed in >95% of the patients. Thrombocytopenia was the most frequent hematological finding (80%), All patients were treated with meglumine antimonate; 20 (24%) of them were partially treated on an outpatient basis. Rapid clinical response was noted in all patients but one. Five patients relapsed; 3 responded to reintroduction of meglumine antimonate, 1 responded to liposomal amphotericin B, and 1 underwent splenic artery ligation. We conclude that pentavalent antimonials remain the first choice of treatment for visceral leishmaniasis in immunocompetent children in areas where resistance has not become a problem, It is possible to treat affected patients with outpatient administration of these agents, making them feasible options for therapy.
1999

abstract No: 

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Full conference title: 

39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
    • ICAAC 39th