Virulence factors of Candida spp. and persistence of candiduria in patients with urinary catheters

H. Akalin, B. Ener, F. Kahveci, S. Akçaglar, S. Gürcan, O. Töre

Abstract: 

In this study, the patients who had developed candiduria in the intensive care unit (medical and surgical) (ICU) were followed prospectively for persistence of candiduria after changed of indwelling urethral catheter and the correlation between persistence and virulence factors such as proteinase enzyme activity, epithelial adhesion were investigated. Inclusion criteria of the study were; presence of indwelling urethral catheter, received broad spectrum antibiotic therapy during candiduria, not received antifungal therapy before enrolment, not received corticosteroid and immunosupressive therapy, absence of HIV infection and neutropenia and absence of SIRS. Candiduria was defined as the presence in cultures of =10 3 cfu/mL. When the candiduia was detected, catheter was changed and a second urine culture was performed within 24-72 h. The clearence was defined as the absence of the growth in second urine culture and persistence was defined as the presence of the growth of the same Candida spp. (persistence of candiduria) in second urine culture. This study was conducted from January 1997 to December 1998 and 459 patients who were hospitalized in ICU were followed prospectively. Of the 459 patients, 53 had candiduria (11.5%) and 4 of the 53 patients who had candiduria developed candidaemia (7.5%). Thirty-four patients with candiduria who met the inclusion criteria of the study were included. There were 16 females and 18 males with a mean age of 58 years. Candiduria persisted in 19 of 34 patients(56%)(group 1) and cleared in 15 of 34 patients(44%)(group 2) after urinary catheter was changed. When we compared for epithelial adhesion, proteinase activity and distribution of Candida spp., no statistically significant differences were found between two groups. The persistence was significantly higher in males than females (14/18 vs. 5/16, P
2001

abstract No: 

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Full conference title: 

11th European Congress of Clinical Microbiology and Infectious Diseases
    • ECCMID 11th (2001)