THE velvetregulators in Aspergilli

Heesoo Park, JJae-Hyuk Yu

Author address: 

Bacteriology, University of Wisconsin Madison, Madison, WI


The velvetregulators are the key players coordinating fungal growth, differentiation and secondary metabolism in response to various internal and external cues. All velvetfamily proteins contain the conserved velvet homology motif (~190 a.a.), and define a novel class of fungal specific transcription factors with the DNA binding ability. Some velvetregulators form time and/or cell type specific complexes with other velvetregulators or non-velvet proteins. These complexes play differential roles in regulating growth, development, sporogenesis and toxigenesis. Among the velvet complexes, the VelBVosA hetero-complex acts as a functional unit conferring the completion of sporogenesis (focal trehalose biogenesis and spores wall completion), and the long-term viability of spore, and the attenuation of conidial germination in the model filamentous fungus Aspergillus nidulans. Both velB and vosA are activated by AbaA in developing cells, and the VelB-VosA complex plays a dual role in activating genes associated with spore maturation and in exerting negative feedback regulation of developmental genes. Interestingly, the VelB-VosA complex plays similar yet somewhat distinct roles in spore maturation, dormancy and germination in Aspergillus fumigatus and Aspergillus flavus. A comprehensive model depicting the roles of the velvet regulators in aspergilli is presented.

abstract No: 


Full conference title: 

27th Fungal Genetics Conference
    • Fungal Genetics Conference 27th (2013)