Use of MSCs to offer dual benefits of immune suppression or immune reconstruction in a patient with aplastic anaemia complicated by invasive sino-orbital aspergillosis

Hakan Ozdogu, Mahmut Yeral, Can Boga, Ilknur Ilknur Kozanoglu

Author address: 

Adana, TR


Cultured human bone marrow mesenchymal cells (MSCs) have immunomodulatory and tissue regenerative properties. This report summarizes the result of post-transplant treatment with MSCs of a 26-year-old aplastic anemia patient complicated by invasive sino-orbital aspergillosis. The patient treated with MSCs to expedite the dual effects of MSCs in immune reconstitution: suppression against alloreactive T cells and facilitation of re-engraftment process. This complicated patient did not developed acute and chronic graft versus host disease. Aspergillus infection healed completly. The engraftment failure also recovered without any complication. During his current visit at fourth year after transplantation, he was in hematological remission. Human MSCs seems to have a role on prevention, or overcoming immunological complications in the patients who undergo stem cell transplantation. 


Full conference title: 

Annual Meeting of European Society for Blood and Marrow Transplantation
    • EBMT 39th (2013)