Usage of fungolon in the treatment of otomycoses

Hovhannisyan, Y.K.H.

Author address: 

Yerevan State University, YEREVAN, Armenia


Today the fungal infections have become a major health care problem. Over the last years the problem of human mycotic diseases obtains the important social implication because of substantial growth of their frequency. One of the reasons of significant affection with fungal diseases among the population is insufficient awareness about fungal infection, ways of its distribution and prophylaxis measures. Treatment of mycoses has certain difficulties and it demands complex therapy. The purpose of this research was usage of the preparation Fungolon in clinical practice in patients with fungal infections. The current studies were carried out in the Mycological Laboratory of the Department of Botany, Yerevan State University and Department of Otorhinolaringology (ENT) of the clinical hospital N3, city Yerevan. The strains isolated from otomycoses suffering patients were studied in 2-10 days after inoculation. The main pathogens of ENT-organs fungal diseases are yeast-like fungi of genera Candida, Geotrichum; mould fungi of genera Aspergillus, Penicillium, Scopulariopsis, Mucor, Cephalosporium, Alternaria and others. The diagnosis had been conducted on the basis of clinical and laboratory data. We had examined 32 patients with otomycoses in the age of 20-66 years. Depending on an applied method of treatment patients had been divided into 2 clinical groups: I group - (15 patients) ' had been conducted local treatment with 1% Nitrofungin solution 3 times during the day within 2 weeks. II group - (17 patients) - alongside with local application of 1% Nitrofungin solution also had been prescribed Fungolon (100 mg) daily within 2 weeks. Observed patients from first group had full recovery in 55%, patients from the second clinical group that had combined treatment had full recovery in 82%. Efficiency of therapy has been defined on two parameters: absence of clinical presentations (itch, stuffiness in ear, and patch in acoustic duct) and negative laboratory research of smear from acoustic duct. Fungal processes of ENT are inclined to relapse; therefore it is necessary to have repeated courses of treatment. Thus, it is possible to note, that combined usage of Fungolon (Flukonazol) with Nitrofungin, is effective in treatment of otomycoses, and it can be used as a preventive measure among the patients that receiving antibacterial therapy. As a whole under the correct medical treatment of ENT mycoses therapy is effective enough.

abstract No: 


Full conference title: 

3rd Trends in Medical Mycology
    • TIMM 3rd (2011)