Toll-Like Receptors in Defense to Candidiasis and Aspergillosis.

MIHAI G. NETEA, MD

Author address: 

Univ. Hosp. Nijmegen, Nijmegen, Netherlands.

Abstract: 

Toll-like receptors (TLRs) have been recently described as the most important class of pattern-recognition receptors in mammals. Initially described in Drosophilla for mediating antifungal defense to aspergillus fumigatus, recent studies identified TLRs as crucial for recognition of Candida albicans and aspergillus fumigatus by human cells. Recognition of these two most important fungal pathogens in humans by TLR2 and TLR4 results in activation of intracellular pathways leading to cytokine production. These events prove crucial for mounting an effective initial antifungal defense, and bridge the gap between the innate and acquired immunity. Moreover, new findings in the differential pathways mediated by various TLRs provide important insights in the mechanisms used by these pathogens to evade the immune system, and opens potential new avenues for the treatment of these serious infections.
2003

abstract No: 

1137

Full conference title: 

43rd Interscience Conference on Antimicrobial Agents
    • ICAAC 43rd