territrem B

Toxin: 

n

Systematic name: 

4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3,4,5-trimethoxyphenyl)-, (4aR,6aR,12aS,12bS)- 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexa

Molecular formulae: 

C29H34O9

Molecular weight: 

526.575

Chem abstract number: 

70407-20-4

Literature reference: 

Ling KH, Yang CK, Peng FT. Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl Environ Microbiol. 1979 Mar;37(3):355-7.
Chen JW, Luo YL, Hwang MJ, Peng FC, Ling KH. Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J Biol Chem. 1999 Dec 3;274(49):34916-23.
Chen JW, Ling KH. Territrems: Naturally Occurring Specific Irreversible Inhibitors of Acetylcholinesterase. J Biomed Sci. 1996 Jan;3(1):54-58.

Chemical type: 

Toxicity: 

mouse LD50 intraperitoneal 9060ug/kg (9.06mg/kg) Applied and Environmental Microbiology. Vol. 47, Pg. 98, 1984. Link to PubMed

History: 

Structure image: 

Aspergillus Species known to produce this metabolite: 

Date uploaded: 

2008-07-14 10:46:53