Vulvovaginitis by Candida is a common gynecological pathology and C. albicans is the most frequent involved specie .The most of C. albicans isolated from vaginal samples are susceptible to FZ and there are few reports about the prevalence of resistant strains. Other species as C. glabrata have been associated to recurrence because they have higher minimal inhibitory concentrations (MICs) than C. albicans to FZ. Objective: To determine the susceptibility of yeasts isolated from vaginal samples with the purpose to give an useful information to physicians for the management of this pathology. Materials and Methods: 255 strains isolated from vaginal samples were studied in a microbiology lab. Results: SPECIES n % MIC50 (••••g/mL) MIC90 (••••g/mL) MIC RANGE (••••g/mL) C. albicans 219 86 0,25 2 0,25-128 C. glabrata 25 10 16 32 0,25-128 C. krusei 3 1 32 32 16-32 C. tropicalis 1 0,3 0,25 0,25 0,25 S. cerevisiae 7 2,7 8 16 0,25-16 The 86% (213/219) of isolated C. albicans were susceptible to FZ (MICs 16 µg/mL. The MICs50 y MICs90 where higher for C. krusei (resistant to FZ), C. glabrata and S. cerevisiae than the other species Conclusions: This results confirm the importance of an appropiate diagnostic of the isolated yeasts because they show different susceptibilities to FZ and they could support a therapeutic failure.
Full conference title:
The 15 th Congress of the International Society for Human and Animal Mycology
- ISHAM 15th (2003)