Objective: To study species distribution and prevalence of susceptibility to fluconazole and voriconazole among Candida spp., isolated from blood of hospitalized patients in Saint Petersburg. Methods: Susceptibility testing was performed according to CLSI M44A document. Results: During years 2003-2008 145 Candida spp. strains have been cultured from blood of patients in several tertiary hospitals in Saint Petersburg, Russia and transferred for species identification and susceptibility testing to reference mycological laboratory (Kashkin Research Institute of Medical Mycology). Species distribution was as follows: C. albicans 36 strains (24,8%), C. parapsilosis 34 (23,4%), C. guilliermondii 28 (19,3%), C. glabrata 14 (9,7%), C. tropicalis 9 (6,2%), C. krusei 5 (3,4%), C. lusitaniae 4 (2,8%), C. famata 2 (1,4%), C. lipolytica 1 (0,7%), C. dubliniensis 1 (0,7%), C. pelliculosa 1 (0,7%), Candida sp. 10 (6,9%). All isolates were tested for susceptibility to fluconazole. On the whole, 33 (22,8%) strains were resistant ( R) or susceptible dose-dependent (SDD) to this drug. All C. albicans and all except one C. parapsilosis strains were susceptible to fluconazole. All C. krusei isolates were R. Low susceptibility (R, SDD) was found in 13 (46,4%) C. guilliermondii strains and 12 (85,7%) C. glabrata isolates. Susceptibility to voriconazole was tested in 56 Candida spp. strains, isolated from blood during 2006-2008. On the whole, 8 (14,3%) isolates were R or showed intermediate ( I ) susceptibility to this antifungal. Among strains with low susceptibility (R, I) to voriconazole species distribution was as follows: C. guilliermondii 3 strains, C. krusei 2, C. glabrata 2, C. parapsilosis 1. Conclusions: 1. Candida non-albicans species caused 75,2% of cases of candidaemia in Saint Petersburg. 2. Among aetiologic agents of candidaemia prevalence of susceptibility to fluconazole was 77,2% and to voriconazole 85,7%.
Full conference title:
19th European Congress of Clinical Microbiology and Infectious Diseases
- ECCMID 19th (2009)