Background: To assess susceptibility of Candida blood isolates to FLU and VOR. Methods: Strains were tested with disk-diffusion method according M44-P NCCLS (CLSI) guidelines and assessed with BIOMIC® system within ARTEMIS Disk study. For VOR preliminary breakpoints were used to stratify strains between susceptible (S), susceptible dose-depended (SDD) and resistant (R) categories. Results: A total of 131 Candida blood isolates were tested in 2003-2005 period. The major tested species were as follows: C.albicans 46 (35.1%), C.parapsilosis 25 (19.1%) and Candida spp. 17 (13%). The main types of departments the strains were gathered from were: therapy (42.7%), surgical ICU (12.2%), hematology/oncology and medical ICU (both 11.5%). The susceptibility data are presented in Table 1. Table 1. Susceptibility data for FLU and VOR. Conclusions: FLU and VOR are highly active against main causative agent - C.albicans. C.glabrata is the least susceptible species among Candida genus both for FLU and VOR. Against C.krusei VOR shows high activity in contrast to FLU.