Today, due to observation of drug resistance of the fungal and bacterial agents to some anti-fungal and anti-bacterial drugs and daily-increasing enhancement of fungal and bacterial infections, requirement for new compounds replaced with these drugs is to be felt excessively. Thiazole derivatives which have plentiful applications from biological viewpoint can be an appropriate replacement for the anti fungal and anti bacterial drugs and may have better effect, with less complications, for the host compared to anti-fungal and anti-bacterial drugs. In this research, using microdilution broth test (MIC), rate of drug sensitivity of three drugs known as Fluconazole, Itraconazole and Gentamicin along with newly synthesized derivatives of Thiazole was assessed on the fungi and bacteria. Derivatives on the yeast, moulds and bacteria, it was specified that, for derivative of 1 and 3- thiazole types 2d, they wrer reported that MIC 90, respectively, Candida albicans 200 , Fusarium solani 25 , Trichophyton mentagrophytes 50, Aspergillus fumigatus , Bacillus subtillis 50, Pseudomonas aeruginosa 200 , Escherichia coli 12.5; for 1,3-thiazole type 20 derivative, Candida albicans 200, Fusarium solani 25, Trichophyton mentagrophytes 100, Aspergillus fumigatus 12.5, Bacillus substilis is 200, Pseudomonas aeruginosa 400 and Escherichia coli is equal to 25. Usage of Thiazole derivatives can not be effectiveness as antimicrobial on these microbes and these derivatives compared to the above antibiotics didn't have higher inhibition power.
Full conference title:
- ISHAM 19th (2015)