Surveillance of cryptococcosis in Alabama, 1992-1994

Thomas, C. J.;Lee, J. Y.;Conn, L. A.;Bradley, M. E.;Gillespie, R. W.;Dill, S. R.;Pinner, R. W.;Pappas, P. G.

Author address: 

Thomas, CJ, Univ Alabama, Div Infect Dis, Mycoses Study Grp, 335 BDB-1808 7th Ave S, Birmingham, AL 35294 USA


PURPOSE: Although cryptococcosis is a significant opportunistic infection among patients with human immunodeficiency virus (HIV), there is conflicting information on rates of cryptococcosis among HIV-positive and HIV-negative patients. Precise state-wide epidemiologic data for cryptococcosis are not available in Alabama.METHODS: We conducted an active laboratory and hospital medical record-based surveillance Fur cryptococcosis in Alabama from October 1, 1992 to September 30, 1994. A case of cryptococcosis was defined as a patient's initial episode of cryptococcal disease and based on either a positive culture for C. neoformans from any normally sterile site, a positive latex agglutination serologic test for cryptococcal antigen in CSF or serum, or histopathologic findings consistent with C. neoformans.RESULTS: Over the two year period, 153 cases were identified, The diagnosis was based on positive culture (37%), positive antigen (24%), positive autopsy culture (2%), and histopathologic findings (4%). Further, 33% of the total cases were diagnosed from combined positive culture, antigen, or histopathology. Of the total 153 cases, 55% were in HIV-positive patients omit 44% were in HIV negative individuals and one case (1%) had an unknown HN status. The overall annual incidence rate of cryptococcosis was 1.89 cases per 100,000 population. The incidence was 1638.7 per 100,000 in the HIV-positive population and 0.84 per 100,000 in the HIV-negative populationCONCLUSION: The first Alabama statewide active surveillance system for cryptococcosis confirms previous observations that rates of cryptococcosis are consistently higher in HIV-infected individuals than in their HIV-negative counterparts. In Alabama, cryptococcosis occurs more commonly in urban residents and in men. Cryptococcosis in HIV-positive persons is more likely to occur in the 20 to 44 year age group, whereas cryptococcosis in HIV-negative persons is more likely to occur in those greater than 45 years old. (C) 1998 Elsevier Science Inc.

abstract No: 


Full conference title: 

33rd Annual Meeting of the Infectious-Diseases-Society-of- America
    • IDSA 33rd