Suppressor mutagenesis reveals EsaA as regulator of secondary metabolism.

Alexandra A. Soukup, Joseph Strauss, and Nancy P. Keller

Author address: 

Department of Genetics and Department of Medical Microbiology and Immunology, University of Wisconsin Madison. 3455 Microbial Sciences 1550 Linden Drive Madison,


Regulation of secondary metabolite (SM) gene clusters in Aspergillus nidulans has been shown to occur through cluster specific transcription factors (AflR), or through global regulators of chromatin structure such as histone methyltransferases (ClrD, CclA), histone deacetylases (HdaA), or the putative histone methyltransferase LaeA. Deletion of laeA results in drastically decreased amounts of multiple secondary metabolites. A multi-copy suppressor screen for genes capable of returning SM to the DeltalaeA mutant resulted in identification of the histone acetyltransferase AN10956.4, here referred to as esaA. Overexpression of esaA results in the induction of numerous SM clusters as well as sexual development. This effect is light dependent, emphasizing the importance of the velvet complex in regulating these stages of fungal development.

abstract No: 


Full conference title: 

26th Fungal Genetics Conference
    • Fungal Genetics Conference 26th (2005)