SPK-843, a new polyene antifungal

SPK-843, a new polyene antifungal, exhibited dose dependent efficacy on murine pulmonary aspergillosis models. Doses of SPK-843 higher than 1.0 mg/kg exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated dose of amphotericin B (1.0 mg/kg) and AmBisome® at 8.0 mg/kg