Similar Is Not The Same: Differences In The Function Of The (Hemi8208;) Cellulolytic Regulator XlnR (Xlr1/Xyr1) In Filamentous Fungi

Sylvia Klaubauf,Hari Mander Narang, Evy Battaglia, Tetsuo Kobayashi, Kurt Brunner, Astrid R. Mach Aigner, Robert L. Mach, Ronald de Vries

Author address: 

CBS-KNAW Fungal Biodiversity Centre, Uppsalalaan 8, 3584CT Utrecht, the Netherlands, Microbiology, Utrecht University, Padualaan 8, 3584CH Utrecht, the Netherlands, Department of Biological Mechanisms and Functions, Graduate School of Bioagri


The (hemi8208;) cellulolytic regulator XlnR (Xlr1/Xyr1) is a major factor in fungal xylan and cellulose degradation as well as in the utilization of D8208;xylose via the pentose catabolic pathway (PCP). XlnR homologues are commonly found in filamentous ascomycetes and often assumed to have the same function in different fungi. However, a comparison of the saprobe Aspergillus niger and the plant pathogen Magnaporthe oryzae showed different phenotypes for deletion strains of XlnR. In this study wild type and xlnR/xlr1/xyr1 mutants of six fungi were compared: Fusarium graminearum, M. oryzae, Trichoderma reesei, A. niger, Aspergillus nidulans and Aspergillus oryzae. The comparison included growth profiling on relevant substrates and detailed analysis of protein profiles of extracellular enzymes and extracellular enzyme activities. The data resulting from this comparison demonstrate significant differences in the influence of XlnR and its orthologs on plant polysaccharide degradation by these fungi. Highlights of the study will be presented.

abstract No: 


Full conference title: 

11 th European Conference on Fungal Genetics
    • ECFG 11th (2012)