Serological tools: new data for the diagnosis of opportunistic mycoses

M. Moragues

Author address: 

Deparment of Enfermerıá, Universidad del Paı’s Vasco-, Bilbao, Spain

Abstract: 

Concurrence of immunosuppression with certain aggressive medical/ chirurgical procedures increases the risk for acquiring an Invasive Fungal Disease (IFD). Some examples are patients undergoing hematopoietic stem cell transplantation due to haematological malignancies, solid organ transplant receptors, HIV patients, pre-mature neonates[ 3DOTS] The most frequent fungi causing opportunistic IFDs belong to genus Candida Aspergillus and Cryptococcus, followed by Zygomycetes, hyaline moulds (Fusarium, Scedosporium[3DOTS]), and a wide variety of dematiaceous fungi [Pfaller, CID 2006; Richardson, CMI 2008]. The diagnosis of IFD is difficult. In a study of 1017 autopsies (1989 2003) of haematologic malignancies patients [Chamilos. Haematologica 2006], IFD was identified in 314 (31%), and 75% had not been diagnosed antemortem. Available diagnostic tools were not as efficient as expected: low sensitivity, slow procedures, negative results not excluding IFD, invasive sampling procedures (bronchoalveolar lavage, BAL), culture unable to differentiate invasion from contamination or colonization[3DOTS] The diagnosis of mycoses requires the combination of clinical data and laboratory tests including:
2011

abstract No: 

W03.4

Full conference title: 

Trends in Medical Mycology, 5th
    • TIMM 5th (2013)